Max Schottelius : Pioneer in Pheochromocytoma

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Bausch , B , Tischler , A S , Schmid , K W , Leijon , H , Eng , C & Neumann , H P H 2017 , ' Max Schottelius : Pioneer in Pheochromocytoma ' , Journal of the Endocrine Society , vol. 1 , no. 7 , pp. 957-964 . https://doi.org/10.1210/js.2017-00208

Title: Max Schottelius : Pioneer in Pheochromocytoma
Author: Bausch, Birke; Tischler, Arthur S.; Schmid, Kurt W.; Leijon, Helena; Eng, Charis; Neumann, Hartmut P. H.
Contributor: University of Helsinki, Department of Pathology
Date: 2017-07-01
Language: eng
Number of pages: 8
Belongs to series: Journal of the Endocrine Society
ISSN: 2472-1972
URI: http://hdl.handle.net/10138/299245
Abstract: First descriptions of diseases attract tremendous interest because they reveal scientific insight even in retrospect. Max Schottelius, the pathologist contributing the first histological description of pheochromocytoma, remains anonymous. We reviewed the description by Schottelius and weighed the report in modern context. Schottelius described the classical diagnostic elements of pheochromocytoma, including the brown appearance after exposure to chromate-containing Mueller's fixative. This color change, known as chromaffin reaction, results fromoxidation of catecholamines and is reflected in the name pheochromocytoma, meaning dusky-colored chromate-positive tumor. Thus Schottelius performed the first known histochemical contribution to diagnosis, which is today standard with immunohistochemistry for chromogranin. Copyright (c) 2017 Endocrine Society This article has been published under the terms of the Creative Commons Attribution NonCommercial, No-Derivatives License (CC BY-NC-ND).
Subject: pheochromocytoma
chromaffine tumors
Max Schottelius
Muller's solution
3121 General medicine, internal medicine and other clinical medicine
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