Dairy consumption, systolic blood pressure, and risk of hypertension : Mendelian randomization study

Show full item record



Permalink

http://hdl.handle.net/10138/299260

Citation

CHARGE Consortium & Ding , M 2017 , ' Dairy consumption, systolic blood pressure, and risk of hypertension : Mendelian randomization study ' , BMJ : British Medical Journal , vol. 356 , 1000 . https://doi.org/10.1136/bmj.j1000

Title: Dairy consumption, systolic blood pressure, and risk of hypertension : Mendelian randomization study
Author: CHARGE Consortium; Ding, Ming
Date: 2017-03-16
Language: eng
Number of pages: 10
Belongs to series: BMJ : British Medical Journal
ISSN: 1756-1833
URI: http://hdl.handle.net/10138/299260
Abstract: OBJECTIVE To examine whether previous observed inverse associations of dairy intake with systolic blood pressure and risk of hypertension were causal. DESIGN Mendelian randomization study using the single nucleotide polymorphism rs4988235 related to lactase persistence as an instrumental variable. SETTING CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium. PARTICIPANTS Data from 22 studies with 171 213 participants, and an additional 10 published prospective studies with 26 119 participants included in the observational analysis. MAIN OUTCOME MEASURES The instrumental variable estimation was conducted using the ratio of coefficients approach. Using metaanalysis, an additional eight published randomized clinical trials on the association of dairy consumption with systolic blood pressure were summarized. RESULTS Compared with the CC genotype (CC is associated with complete lactase deficiency), the CT/TT genotype (TT is associated with lactose persistence, and CT is associated with certain lactase deficiency) of LCT-13910 (lactase persistence gene) rs4988235 was associated with higher dairy consumption (0.23 (about 55 g/day), 95% confidence interval 0.17 to 0.29) serving/day; P CONCLUSION The weak inverse association between dairy intake and systolic blood pressure in observational studies was not supported by a comprehensive instrumental variable analysis and systematic review of existing clinical trials.
Subject: DOSE-RESPONSE METAANALYSIS
CONTROLLED-TRIALS
CARDIOVASCULAR-DISEASE
INCIDENT HYPERTENSION
METABOLIC SYNDROME
GENETIC-VARIANTS
BODY-WEIGHT
MILK
ADULTS
FAT
3121 Internal medicine
3143 Nutrition
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
bmj.j1000.full.pdf 801.3Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record