Follicle-Stimulating Hormone Levels and Subclinical Atherosclerosis in Older Postmenopausal Women

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http://hdl.handle.net/10138/299269

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Bertone-Johnson , E R , Virtanen , J K , Nurmi , T , Niskanen , L , Mursu , J , Voutilainen , S , Ronkainen , K , Kauhanen , J & Tuomainen , T-P 2018 , ' Follicle-Stimulating Hormone Levels and Subclinical Atherosclerosis in Older Postmenopausal Women ' , American Journal of Epidemiology , vol. 187 , no. 1 , pp. 16-26 . https://doi.org/10.1093/aje/kwx174

Title: Follicle-Stimulating Hormone Levels and Subclinical Atherosclerosis in Older Postmenopausal Women
Author: Bertone-Johnson, Elizabeth R.; Virtanen, Jyrki K.; Nurmi, Tarja; Niskanen, Leo; Mursu, Jaakko; Voutilainen, Sari; Ronkainen, Kimmo; Kauhanen, Jussi; Tuomainen, Tomi-Pekka
Contributor: University of Helsinki, Endokrinologian yksikkö
Date: 2018-01-01
Language: eng
Number of pages: 11
Belongs to series: American Journal of Epidemiology
ISSN: 0002-9262
URI: http://hdl.handle.net/10138/299269
Abstract: Recent studies of perimenopausal women suggest that follicle-stimulating hormone (FSH) levels may be associated with atherosclerosis, independent of estradiol. Whether FSH is related to atherosclerosis in older postmenopausal women, who have completed the menopausal transition, remains unknown. We assessed the relationship of serum FSH and estradiol levels with carotid artery intima-media thickness (IMT) among 587 postmenopausal participants in the Kuopio Ischemic Heart Disease Risk Factor Study (Kuopio, Finland). Participants were aged 53-73 years and not using hormone therapy at baseline (1998-2001). Mean IMT was measured via high-resolution ultrasonography. We observed a significant inverse association between FSH levels and IMT. Mean IMTs among women in quartiles 1-4 of FSH were 0.94 mm, 0.91 mm, 0.87 mm, and 0.85 mm, respectively (P-trend <0.001). After adjustment for age, estradiol, testosterone, body mass index (weight (kg)/height (m)(2)), lipids, and other factors, FSH levels remained significantly associated with IMT (regression coefficients for quartiles 2-4 vs. quartile 1 were -0.038, -0.045, and -0.062, respectively; P-trend = 0.01). Findings were strongest in women aged 64-73 years (P-trend = 0.006) and did not vary by body mass index. In contrast, estradiol levels were not related to IMT. In summary, high postmenopausal FSH levels were associated with a lower atherosclerotic burden, independent of estradiol, adiposity, and other factors. Our findings warrant replication and the further exploration of potential underlying mechanisms.
Subject: atherosclerosis
carotid intima-media thickness
estradiol
follicle-stimulating hormone
postmenopausal women
INTIMA-MEDIA THICKNESS
ENDOGENOUS SEX-HORMONES
MENOPAUSAL TRANSITION
CAROTID ATHEROSCLEROSIS
MYOCARDIAL-INFARCTION
CARDIOVASCULAR RISK
BINDING-PROTEIN
HEART-DISEASE
NATION SWAN
ACTIVIN-A
3142 Public health care science, environmental and occupational health
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