Metabolic syndrome associates with left atrial dysfunction

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Nyman , K , Granér , M , Pentikäinen , M O , Lundbom , J , Hakkarainen , A , Sirén , R , Nieminen , M S , Taskinen , M-R , Lundbom , N & Lauerma , K 2018 , ' Metabolic syndrome associates with left atrial dysfunction ' , Nutrition, Metabolism and Cardiovascular Diseases , vol. 28 , no. 7 , pp. 727-734 .

Title: Metabolic syndrome associates with left atrial dysfunction
Author: Nyman, K.; Granér, M.; Pentikäinen, M.O.; Lundbom, J.; Hakkarainen, A.; Sirén, R.; Nieminen, M.S.; Taskinen, M.-R.; Lundbom, N.; Lauerma, K.
Contributor organization: Department of Diagnostics and Therapeutics
University of Helsinki
HUS Medical Imaging Center
HUS Heart and Lung Center
Marja-Riitta Taskinen Research Group
Kardiologian yksikkö
Diabetes and Obesity Research Program
Research Programs Unit
Department of Medicine
Department of General Practice and Primary Health Care
HUS Internal Medicine and Rehabilitation
Date: 2018-07
Language: eng
Number of pages: 8
Belongs to series: Nutrition, Metabolism and Cardiovascular Diseases
ISSN: 0939-4753
Abstract: Background and aims: Obesity and metabolic syndrome (MetS) are risk factors of atrial fibrillation (AF), but limited data exist on their effect on left atrial (LA) function. The aim of the study was to evaluate the effects of cardiac, hepatic and intra-abdominal ectopic fat depots and cardiometabolic risk factors on LA function in non-diabetic male subjects. Methods and results: Myocardial and hepatic triglyceride contents were measured with 1.5T H-1-magnetic resonance spectroscopy and LA and left ventricular function, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), epicardial and pericardial fat by magnetic resonance imaging (MRI) in 33 men with MetS and 40 men without MetS. LA volumes were assessed using a novel three-chamber orientation based MRI approach. LA ejection fraction (EF) was lower in MetS patients than in the control group (44 +/- 7.7% in MetS vs. 49 +/- 8.6% in controls, p = 0.013) without LA enlargement, indicating LA dysfunction. LA EF correlated negatively with waist circumference, body mass index, SAT, VAT, fasting serum insulin, and homeostasis model assessment of insulin resistance index, and positively with fasting serum high-density lipoprotein cholesterol. VAT was the best predictor of reduced LA EF. Conclusions: MetS associates with subclinical LA dysfunction. Multiple components of MetS are related to LA dysfunction, notably visceral obesity and insulin resistance. Further studies are needed to elucidate the role of mechanical atrial remodeling in the development of AF. (C) 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
Subject: Cardiovascular magnetic resonance
proton magnetic resonance spectroscopy
metabolic syndrome
left atrial
ejection fraction
atrial remodeling
visceral adipose tissue
cardiac steatosis
3121 General medicine, internal medicine and other clinical medicine
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion

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