Metabolic syndrome associates with left atrial dysfunction

Show simple item record Nyman, K. Granér, M. Pentikäinen, M.O. Lundbom, J. Hakkarainen, A. Sirén, R. Nieminen, M.S. Taskinen, M.-R. Lundbom, N. Lauerma, K. 2019-02-20T22:23:32Z 2019-02-21T22:00:18Z 2018-07
dc.identifier.citation Nyman , K , Granér , M , Pentikäinen , M O , Lundbom , J , Hakkarainen , A , Sirén , R , Nieminen , M S , Taskinen , M-R , Lundbom , N & Lauerma , K 2018 , ' Metabolic syndrome associates with left atrial dysfunction ' , Nutrition, Metabolism and Cardiovascular Diseases , vol. 28 , no. 7 , pp. 727-734 .
dc.identifier.other PURE: 99353444
dc.identifier.other PURE UUID: 091791e6-562d-4205-9363-09700e10654a
dc.identifier.other RIS: urn:CF3D7DBF7850CDC755ECA2FB1359ECB0
dc.identifier.other Scopus: 85047209578
dc.identifier.other WOS: 000435224800011
dc.identifier.other ORCID: /0000-0003-4150-3141/work/55618561
dc.identifier.other ORCID: /0000-0002-6229-3588/work/90757068
dc.description.abstract Background and aims: Obesity and metabolic syndrome (MetS) are risk factors of atrial fibrillation (AF), but limited data exist on their effect on left atrial (LA) function. The aim of the study was to evaluate the effects of cardiac, hepatic and intra-abdominal ectopic fat depots and cardiometabolic risk factors on LA function in non-diabetic male subjects. Methods and results: Myocardial and hepatic triglyceride contents were measured with 1.5T H-1-magnetic resonance spectroscopy and LA and left ventricular function, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), epicardial and pericardial fat by magnetic resonance imaging (MRI) in 33 men with MetS and 40 men without MetS. LA volumes were assessed using a novel three-chamber orientation based MRI approach. LA ejection fraction (EF) was lower in MetS patients than in the control group (44 +/- 7.7% in MetS vs. 49 +/- 8.6% in controls, p = 0.013) without LA enlargement, indicating LA dysfunction. LA EF correlated negatively with waist circumference, body mass index, SAT, VAT, fasting serum insulin, and homeostasis model assessment of insulin resistance index, and positively with fasting serum high-density lipoprotein cholesterol. VAT was the best predictor of reduced LA EF. Conclusions: MetS associates with subclinical LA dysfunction. Multiple components of MetS are related to LA dysfunction, notably visceral obesity and insulin resistance. Further studies are needed to elucidate the role of mechanical atrial remodeling in the development of AF. (C) 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Nutrition, Metabolism and Cardiovascular Diseases
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Cardiovascular magnetic resonance
dc.subject proton magnetic resonance spectroscopy
dc.subject metabolic syndrome
dc.subject obesity
dc.subject left atrial
dc.subject ejection fraction
dc.subject atrial remodeling
dc.subject visceral adipose tissue
dc.subject cardiac steatosis
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.title Metabolic syndrome associates with left atrial dysfunction en
dc.type Article
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization University of Helsinki
dc.contributor.organization Clinicum
dc.contributor.organization HUS Medical Imaging Center
dc.contributor.organization HUS Heart and Lung Center
dc.contributor.organization Marja-Riitta Taskinen Research Group
dc.contributor.organization Kardiologian yksikkö
dc.contributor.organization Diabetes and Obesity Research Program
dc.contributor.organization Research Programs Unit
dc.contributor.organization Department of Medicine
dc.contributor.organization Department of General Practice and Primary Health Care
dc.contributor.organization HUS Internal Medicine and Rehabilitation
dc.description.reviewstatus Peer reviewed
dc.relation.issn 0939-4753
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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