GenRank : A R/Bioconductor package for prioritization of candidate genes

Visa fullständig post



Kanduri , C & Järvelä , I 2017 , ' GenRank : A R/Bioconductor package for prioritization of candidate genes ' , F1000Research , vol. 6 , 463 .

Titel: GenRank : A R/Bioconductor package for prioritization of candidate genes
Författare: Kanduri, C.; Järvelä, I.
Upphovmannens organisation: Irma Järvelä / Principal Investigator
Department of Medical and Clinical Genetics
University of Helsinki
Datum: 2017
Språk: eng
Sidantal: 9
Tillhör serie: F1000Research
ISSN: 2046-1402
Permanenta länken (URI):
Abstrakt: Modern high-throughput studies often yield long lists of genes, a fraction of which are of high relevance to the phenotype of interest. To prioritize the candidate genes of complex genetic traits, our R/Bioconductor package GenRank ranks genes based on convergent evidence obtained from multiple layers of independent evidence. We implemented three methods to rank genes that integrate gene-level data generated from multiple layers of evidence: (a) the convergent evidence (CE) method aggregates evidence based on a weighted vote counting method; (b) the rank product (RP) method performs a meta-analysis of microarray-based gene expression data, and (c) the traditional method combines p-values. The methods are implemented in R and are available as a package in the Bioconductor repository. ( © 2017 Kanduri C and Järvelä I.
Subject: Article
convergent evidence evidence
data analysis software
gene expression
genetic trait
genetic variation
rank product method
statistical significance
3111 Biomedicine
1184 Genetics, developmental biology, physiology
Referentgranskad: Ja
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion

Filer under denna titel

Totalt antal nerladdningar: Laddar...

Filer Storlek Format Granska
face0948_be8e_4 ... 3_chakravarthi_kanduri.pdf 828.8Kb PDF Granska/Öppna

Detta dokument registreras i samling:

Visa fullständig post