Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

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http://hdl.handle.net/10138/299358

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Atrial Fibrillation Genetics Conso , Int Stroke Genetics Consortium , Pulit , S L , Lyytikäinen , L-P , Seppälä , I , Malik , R , Sinisalo , J , Vlachopoulou , E , Lokki , M-L , Tatlisumak , T & Happola , O 2018 , ' Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes ' , Neurology Genetics , vol. 4 , no. 6 , 293 . https://doi.org/10.1212/NXG.0000000000000293

Title: Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
Author: Atrial Fibrillation Genetics Conso; Int Stroke Genetics Consortium; Pulit, Sara L.; Lyytikäinen, Leo-Pekka; Seppälä, Ilkka; Malik, Rainer; Sinisalo, Juha; Vlachopoulou, Efthymia; Lokki, Marja-Liisa; Tatlisumak, Turgut; Happola, Olli
Contributor: University of Helsinki, Department of Medicine
University of Helsinki, Transplantation Laboratory
University of Helsinki, Medicum
University of Helsinki, Neurologian yksikkö
University of Helsinki, Department of Neurosciences
Date: 2018-12
Language: eng
Number of pages: 8
Belongs to series: Neurology Genetics
ISSN: 2376-7839
URI: http://hdl.handle.net/10138/299358
Abstract: Objective We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. Methods We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. Results We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p <4.4 x 10(-4) in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 x 10(-48)), explaining similar to 20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07,p = 0.004), but no other primary stroke subtypes (all p > 0.1). Conclusions Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.
Subject: ISCHEMIC-STROKE
CAUSATIVE CLASSIFICATION
LIFETIME RISK
EPIDEMIOLOGY
ASSOCIATION
PREVENTION
VARIANTS
ASPIRIN
BURDEN
3112 Neurosciences
3124 Neurology and psychiatry
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