Does vitamin D supplementation improve bone density in vitamin D-deficient children? Protocol for an individual patient data meta-analysis

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http://hdl.handle.net/10138/299359

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Winzenberg , T , Lamberg-Allardt , C , Fuleihan , G E-H , Molgaard , C , Zhu , K , Wu , F & Riley , R D 2018 , ' Does vitamin D supplementation improve bone density in vitamin D-deficient children? Protocol for an individual patient data meta-analysis ' , BMJ Open , vol. 8 , no. 1 , 019584 . https://doi.org/10.1136/bmjopen-2017-019584

Title: Does vitamin D supplementation improve bone density in vitamin D-deficient children? Protocol for an individual patient data meta-analysis
Author: Winzenberg, Tania; Lamberg-Allardt, Christel; Fuleihan, Ghada Ei-Hajj; Molgaard, Christian; Zhu, Kun; Wu, Feitong; Riley, Richard D.
Contributor: University of Helsinki, Department of Food and Nutrition
Date: 2018-01
Language: eng
Number of pages: 7
Belongs to series: BMJ Open
ISSN: 2044-6055
URI: http://hdl.handle.net/10138/299359
Abstract: Introduction Our previous study-level (aggregate data) meta-analysis suggested that vitamin D supplements may be beneficial for bone density specifically in children with vitamin D deficiency. However, the misclassification of vitamin D status inherent in study-level data means that the results are not definitive and cannot provide an accurate assessment of the size of any effect. Therefore, we propose to undertake an individual patient data (IPD) meta-analysis to determine whether the effect of vitamin D supplementation on bone density in children differs according to baseline vitamin D status, and to specifically estimate the effect of vitamin D in children who are vitamin D deficient. Methods and analysis This study has been designed to adhere to the Preferred Reporting Items for Systematic Review and Meta-Analyses of IPD statement. We will include randomised placebo-controlled trials of vitamin D supplementation reporting hone density outcomes at least 6 months after the study commenced in children and adolescents (aged Ethics and dissemination Ethics approval will not be required as the data are to be used for the primary purpose for which they were collected and all original individual studies had ethics approval. Results of the IPD meta-analysis will be submitted for publication in a peer-reviewed journal.
Subject: MINERAL DENSITY
PARTICIPANT DATA
FOREARM FRACTURES
HEALTHY-CHILDREN
BODY-COMPOSITION
AGGREGATE DATA
MASS
GIRLS
WOMEN
TRIAL
3121 General medicine, internal medicine and other clinical medicine
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