Matrix Metalloproteinase-8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri-Implant Diseases

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http://hdl.handle.net/10138/299362

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Al-Majid , A , Alassiri , S , Rathnayake , N , Tervahartiala , T , Gieselmann , D-R & Sorsa , T 2018 , ' Matrix Metalloproteinase-8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri-Implant Diseases ' , International journal of Dentistry , vol. 2018 , 7891323 . https://doi.org/10.1155/2018/7891323

Title: Matrix Metalloproteinase-8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri-Implant Diseases
Author: Al-Majid, Ahmed; Alassiri, Saeed; Rathnayake, Nilminie; Tervahartiala, Taina; Gieselmann, Dirk-Rolf; Sorsa, Timo
Contributor: University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Department of Oral and Maxillofacial Diseases
Date: 2018-09-16
Language: eng
Number of pages: 27
Belongs to series: International journal of Dentistry
ISSN: 1687-8728
URI: http://hdl.handle.net/10138/299362
Abstract: Levels of and especially the degree of activation of matrix metalloproteinase (MMP-8) in oral fluids (i.e., saliva, mouth rinse, gingival crevicular fluid (GCF) and peri-implantitis sulcular fluid (PISF)) increase to pathologically elevated levels in the periodontal and peri-implant diseases. This study aimed at collecting and collating data from previously published studies and determining whether active MMP-8 (aMMP-8) could serve as a biomarker for the diagnosis and prevention of periodontal and peri-implant diseases. The literature search identified a total of 284 articles. Out of 284 articles, 61 articles were found to be relevant. Data obtained from the selected studies were combined, and it indicated that aMMP-8 in oral fluids exerts the strong potential to serve as a useful adjunctive diagnostic and preventive biotechnological tool in periodontal and peri-implant diseases. aMMP-8 can be used alone or in combination with other proinflammatory and/or microbiological biomarkers.
Subject: 313 Dentistry
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