Superhydrophobic Blood-Repellent Surfaces

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Pysyväisosoite

http://hdl.handle.net/10138/299395

Lähdeviite

Jokinen , V , Kankuri , E , Hoshian , S , Franssila , S & Ras , R H A 2018 , ' Superhydrophobic Blood-Repellent Surfaces ' , Advanced Materials , vol. 30 , no. 24 , 1705104 . https://doi.org/10.1002/adma.201705104

Julkaisun nimi: Superhydrophobic Blood-Repellent Surfaces
Tekijä: Jokinen, Ville; Kankuri, Esko; Hoshian, Sasha; Franssila, Sami; Ras, Robin H. A.
Tekijän organisaatio: Esko Markus Kankuri / Principal Investigator
Department of Pharmacology
Medicum
Päiväys: 2018-06-13
Kieli: eng
Sivumäärä: 10
Kuuluu julkaisusarjaan: Advanced Materials
ISSN: 0935-9648
DOI-tunniste: https://doi.org/10.1002/adma.201705104
URI: http://hdl.handle.net/10138/299395
Tiivistelmä: Superhydrophobic surfaces repel water and, in some cases, other liquids as well. The repellency is caused by topographical features at the nano-/microscale and low surface energy. Blood is a challenging liquid to repel due to its high propensity for activation of intrinsic hemostatic mechanisms, induction of coagulation, and platelet activation upon contact with foreign surfaces. Imbalanced activation of coagulation drives thrombogenesis or formation of blood clots that can occlude the blood flow either on-site or further downstream as emboli, exposing tissues to ischemia and infarction. Blood-repellent superhydrophobic surfaces aim toward reducing the thrombogenicity of surfaces of blood-contacting devices and implants. Several mechanisms that lead to blood repellency are proposed, focusing mainly on platelet antiadhesion. Structured surfaces can: (i) reduce the effective area exposed to platelets, (ii) reduce the adhesion area available to individual platelets, (iii) cause hydrodynamic effects that reduce platelet adhesion, and (iv) reduce or alter protein adsorption in a way that is not conducive to thrombus formation. These mechanisms benefit from the superhydrophobic Cassie state, in which a thin layer of air is trapped between the solid surface and the liquid. The connections between water-and blood repellency are discussed and several recent examples of blood-repellent superhydrophobic surfaces are highlighted.
Avainsanat: antithrombogenic
blood-compatible
blood-repellent
nanostructures
superhydrophobic
PLATELET-ADHESION
BIOMEDICAL APPLICATIONS
PROTEIN ADSORPTION
THROMBUS FORMATION
HEART-VALVE
COMPATIBILITY
MECHANISMS
FLOW
INFLAMMATION
COAGULATION
318 Medical biotechnology
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: cc_by_nc
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


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