Superhydrophobic Blood-Repellent Surfaces

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dc.contributor.author Jokinen, Ville
dc.contributor.author Kankuri, Esko
dc.contributor.author Hoshian, Sasha
dc.contributor.author Franssila, Sami
dc.contributor.author Ras, Robin H. A.
dc.date.accessioned 2019-02-23T14:15:01Z
dc.date.available 2019-02-23T14:15:01Z
dc.date.issued 2018-06-13
dc.identifier.citation Jokinen , V , Kankuri , E , Hoshian , S , Franssila , S & Ras , R H A 2018 , ' Superhydrophobic Blood-Repellent Surfaces ' , Advanced Materials , vol. 30 , no. 24 , 1705104 . https://doi.org/10.1002/adma.201705104
dc.identifier.other PURE: 122584726
dc.identifier.other PURE UUID: f4ef22e3-55d5-4513-9902-c8aae04a60ba
dc.identifier.other WOS: 000436455800012
dc.identifier.other Scopus: 85042220142
dc.identifier.uri http://hdl.handle.net/10138/299395
dc.description.abstract Superhydrophobic surfaces repel water and, in some cases, other liquids as well. The repellency is caused by topographical features at the nano-/microscale and low surface energy. Blood is a challenging liquid to repel due to its high propensity for activation of intrinsic hemostatic mechanisms, induction of coagulation, and platelet activation upon contact with foreign surfaces. Imbalanced activation of coagulation drives thrombogenesis or formation of blood clots that can occlude the blood flow either on-site or further downstream as emboli, exposing tissues to ischemia and infarction. Blood-repellent superhydrophobic surfaces aim toward reducing the thrombogenicity of surfaces of blood-contacting devices and implants. Several mechanisms that lead to blood repellency are proposed, focusing mainly on platelet antiadhesion. Structured surfaces can: (i) reduce the effective area exposed to platelets, (ii) reduce the adhesion area available to individual platelets, (iii) cause hydrodynamic effects that reduce platelet adhesion, and (iv) reduce or alter protein adsorption in a way that is not conducive to thrombus formation. These mechanisms benefit from the superhydrophobic Cassie state, in which a thin layer of air is trapped between the solid surface and the liquid. The connections between water-and blood repellency are discussed and several recent examples of blood-repellent superhydrophobic surfaces are highlighted. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Advanced Materials
dc.rights cc_by_nc
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject antithrombogenic
dc.subject blood-compatible
dc.subject blood-repellent
dc.subject nanostructures
dc.subject superhydrophobic
dc.subject PLATELET-ADHESION
dc.subject BIOMEDICAL APPLICATIONS
dc.subject PROTEIN ADSORPTION
dc.subject THROMBUS FORMATION
dc.subject HEART-VALVE
dc.subject COMPATIBILITY
dc.subject MECHANISMS
dc.subject FLOW
dc.subject INFLAMMATION
dc.subject COAGULATION
dc.subject 318 Medical biotechnology
dc.title Superhydrophobic Blood-Repellent Surfaces en
dc.type Article
dc.contributor.organization Esko Markus Kankuri / Principal Investigator
dc.contributor.organization Department of Pharmacology
dc.contributor.organization Medicum
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1002/adma.201705104
dc.relation.issn 0935-9648
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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