Prognostic and diagnostic value of REG4 serum and tissue expression in pancreatic ductal adenocarcinoma

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Saukkonen , K , Hagström , J , Mustonen , H , Lehtinen , L , Carpen , O , Andersson , L C , Seppänen , H & Haglund , C 2018 , ' Prognostic and diagnostic value of REG4 serum and tissue expression in pancreatic ductal adenocarcinoma ' , Tumor Biology , vol. 40 , no. 3 . https://doi.org/10.1177/1010428318761494

Title: Prognostic and diagnostic value of REG4 serum and tissue expression in pancreatic ductal adenocarcinoma
Author: Saukkonen, K.; Hagström, J.; Mustonen, H.; Lehtinen, Laura; Carpen, O.; Andersson, L.C.; Seppänen, H.; Haglund, C.
Contributor: University of Helsinki, Faculty of Medicine
University of Helsinki, Medicum
University of Helsinki, Clinicum
University of Helsinki, HUSLAB
University of Helsinki, Department of Pathology
University of Helsinki, Clinicum
University of Helsinki, Department of Surgery
Date: 2018
Language: eng
Number of pages: 10
Belongs to series: Tumor Biology
ISSN: 1010-4283
URI: http://hdl.handle.net/10138/299669
Abstract: Expression of regenerating islet-derived protein 4 (REG4), a secretory protein involved in cell differentiation and proliferation, is upregulated in inflammatory bowel diseases and in many gastrointestinal malignancies. The prognostic significance of its expression in pancreatic ductal adenocarcinoma is unknown. Our aim was to investigate tumor tissue and serum REG4 expression in pancreatic ductal adenocarcinoma patients. We also evaluated as a control the diagnostic value of serum REG4 level in patients with chronic pancreatitis. Immunohistochemical expression of REG4 was evaluated in 154 surgical specimens and serum REG4 level in 130 samples from pancreatic ductal adenocarcinoma patients treated at Helsinki University Hospital, Finland, in 2000–2011. REG4 tissue and serum expression was assessed in relation to clinicopathological parameters and patient survival. A chronic pancreatitis control group comprised 34 patients who underwent pancreatic resection because of suspicion of malignancy. Significant survival differences were detectable in subgroups: in tumor stages IA–IIA, high serum REG4 level predicted worse survival (p=0.046). In patients with grade I tumor, positive tissue REG4 expression predicted better survival (p=0.006). In multivariate analysis, neither tissue nor serum REG4 expression was independent prognostic factors. Serum REG4 levels were higher in pancreatic ductal adenocarcinoma than in chronic pancreatitis (p=0.002), with diagnostic sensitivity of 45% and specificity of 91%. In logistic regression analysis, a multivariate model with REG4, CA19-9, and age provided sensitivity of 82% and specificity of 79%. REG4 tissue expression is a prognostic marker in subgroups of pancreatic ductal adenocarcinoma patients. Serum REG4 level might be useful in differential diagnosis between pancreatic ductal adenocarcinoma and chronic pancreatitis. © 2018, © The Author(s) 2018.
Subject: pancreatitis associated protein
REG4 protein, human
tumor marker, adult
aged
biosynthesis
blood
chronic pancreatitis
differential diagnosis
female
human
immunohistochemistry
Kaplan Meier method
male
metabolism
middle aged
outcome assessment
pancreas carcinoma
pancreas tumor
procedures
prognosis
proportional hazards model
statistics and numerical data, Adult
Aged
Biomarkers, Tumor
Carcinoma, Pancreatic Ductal
Diagnosis, Differential
Female
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Male
Middle Aged
Outcome Assessment (Health Care)
Pancreatic Neoplasms
Pancreatitis, Chronic
Pancreatitis-Associated Proteins
Prognosis
Proportional Hazards Models
3111 Biomedicine
3122 Cancers
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