Global arginine bioavailability ratio is decreased in patients with major depressive disorder

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Ali-Sisto , T , Tolmunen , T , Viinamäki , H , Mäntyselkä , P , Valkonen-Korhonen , M , Koivumaa-Honkanen , H , Honkalampi , K , Ruusunen , A , Nandania , J , Velagapudi , V & Lehto , S M 2018 , ' Global arginine bioavailability ratio is decreased in patients with major depressive disorder ' , Journal of Affective Disorders , vol. 229 , pp. 145-151 . https://doi.org/10.1016/j.jad.2017.12.030

Title: Global arginine bioavailability ratio is decreased in patients with major depressive disorder
Author: Ali-Sisto, Toni; Tolmunen, Tommi; Viinamäki, Heimo; Mäntyselkä, Pekka; Valkonen-Korhonen, Minna; Koivumaa-Honkanen, Heli; Honkalampi, Kirsi; Ruusunen, Anu; Nandania, Jatin; Velagapudi, Vidya; Lehto, Soili M.
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Medicum
Date: 2018-03-15
Language: eng
Number of pages: 7
Belongs to series: Journal of Affective Disorders
ISSN: 0165-0327
URI: http://hdl.handle.net/10138/299679
Abstract: Background: Major depressive disorder (MDD) is characterized by increased oxidative and nitrosative stress. We compared nitric oxide metabolism, i.e., the global arginine bioavailability ratio (GABR) and related serum amino acids, between MDD patients and non-depressed controls, and between remitted and non-remitted MDD patients. Methods: Ninety-nine MDD patients and 253 non-depressed controls, aged 20-71 years, provided background data via questionnaires. Fasting serum samples were analyzed using ultra-performance liquid chromatography coupled to mass spectrometry to determine the serum levels of ornithine, arginine, citrulline, and symmetric and asymmetric dimethylarginine. GABR was calculated as arginine divided by the sum of ornithine plus citrulline. We compared the above measures between: 1) MDD patients and controls, 2) remitted (n= 33) and non-remitted (n = 45) MDD patients, and 3) baseline and follow-up within the remitted and non-remitted groups. Results: Lower arginine levels (OR 0.98, 95% CI 0.97-0.99) and lower GABR (OR 0.13, 95% CI 0.03-0.50) were associated with the MDD vs. the non-depressed group after adjustments for potential confounders. The remitted group showed a decrease in GABR, arginine, and symmetric dimethylarginine, and an increase in ornithine after the follow-up compared with within-group baseline values. The non-remitted group displayed an increase in arginine and ornithine levels and a decrease in GABR. No significant differences were recorded between the remitted and non-remitted groups. Limitations: The MDD group was not medication-free. Conclusions: Arginine bioavailability may be decreased in MDD. This could impair the production of nitric oxide, and thus add to oxidative stress in the central nervous system.
Subject: Major depressive disorder
Arginine
Citrulline
Ornithine
Global arginine bioavailability ratio
NITRIC-OXIDE SYNTHASES
NMDA RECEPTOR
ACCUMULATION
CHOLESTEROL
METABOLISM
MORTALITY
CHANNEL
DISEASE
MASS
3112 Neurosciences
3124 Neurology and psychiatry
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