Serum MMP-8 and TIMP-1 as prognostic biomarkers in gastric cancer

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Laitinen , A , Hagström , J , Mustonen , H , Kokkola , A , Tervahartiala , T , Sorsa , T , Böckelman , C & Haglund , C 2018 , ' Serum MMP-8 and TIMP-1 as prognostic biomarkers in gastric cancer ' , Tumor Biology , vol. 40 , no. 9 . https://doi.org/10.1177/1010428318799266

Title: Serum MMP-8 and TIMP-1 as prognostic biomarkers in gastric cancer
Author: Laitinen, A.; Hagström, J.; Mustonen, H.; Kokkola, A.; Tervahartiala, T.; Sorsa, T.; Böckelman, C.; Haglund, C.
Contributor: University of Helsinki, Medicum
University of Helsinki, Clinicum
University of Helsinki, II kirurgian klinikka
University of Helsinki, Clinicum
University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Translational Cancer Biology (TCB) Research Programme
University of Helsinki, Department of Surgery
Date: 2018
Language: eng
Belongs to series: Tumor Biology
ISSN: 1010-4283
URI: http://hdl.handle.net/10138/299733
Abstract: Despite gastric cancer being rare nowadays in Western countries, it remains one of the leading causes of cancer death worldwide. The course of the disease varies, so the individual gastric cancer patient’s prognosis is difficult to determine. The need for new biomarkers is crucial. The aim of this study was to evaluate the prognostic value of serum matrix metalloproteinase-8, serum tissue inhibitor of metalloproteinase-1, and tissue matrix metalloproteinase-8 in patients with gastric cancer. Preoperative serum samples from 233 patients with gastric cancer were retrospectively analyzed. Serum levels of matrix metalloproteinase-8 were analyzed with immunofluorometric assay, and tissue inhibitor of metalloproteinase-1 levels were determined by enzyme-linked immunosorbent assay. We also determined the tissue expression of matrix metalloproteinase-8 in 276 gastric cancer samples by immunohistochemistry. Survival data and death causes came from patient records, the Population Register Center of Finland, and Statistics Finland. Patients with a low (131 ng/mL) serum matrix metalloproteinase-8 level had a considerably unfavorable prognosis (p = 0.002). Those patients with a high (≥170 ng/mL) serum tissue inhibitor of metalloproteinase-1 level also had a poor prognosis (p <0.001), and the latter remained significant in multivariable analysis (hazard ratio = 1.85; 95% confidence interval: 1.26–2.72; p = 0.002). The molar ratio of serum matrix metalloproteinase-8 and tissue inhibitor of metalloproteinase-1 levels with low (0.30) molar ratios predicted a worse prognosis (p = 0.020). Tissue matrix metalloproteinase-8 did not influence prognosis. These results suggest that serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase-1, and the ratio of matrix metalloproteinase-8/ tissue inhibitor of metalloproteinase-1 may prove useful biomarkers for prediction of prognosis in patients with gastric cancer. © The Author(s) 2018.
Subject: neutrophil collagenase
tissue inhibitor of metalloproteinase 1
MMP8 protein, human
TIMP1 protein, human
tumor marker, adult
aged
Article
blood sampling
cancer mortality
cancer prognosis
cancer survival
cohort analysis
controlled study
enzyme linked immunosorbent assay
female
Finland
human
human cell
human tissue
immunofluorescence test
immunohistochemistry
major clinical study
male
medical record
prediction
preoperative evaluation
priority journal
protein blood level
protein expression
retrospective study
stomach cancer
adenocarcinoma
blood
follow up
lymph node metastasis
middle aged
pathology
prognosis
secondary
stomach tumor
survival rate
tumor invasion, Adenocarcinoma
Aged
Biomarkers, Tumor
Female
Follow-Up Studies
Humans
Lymphatic Metastasis
Male
Matrix Metalloproteinase 8
Middle Aged
Neoplasm Invasiveness
Prognosis
Retrospective Studies
Stomach Neoplasms
Survival Rate
Tissue Inhibitor of Metalloproteinase-1
3122 Cancers
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