Identification of a Novel Genomic Island Associated with vanD-Type Vancomycin Resistance in Six Dutch Vancomycin-Resistant Enterococcus faecium Isolates

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http://hdl.handle.net/10138/299784

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Top , J , Sinnige , J C , Brouwer , E C , Werner , G , Corander , J , Severin , J A , Jansen , R , Bathoorn , E , Bonten , M J M , Rossen , J W A & Willems , R J L 2018 , ' Identification of a Novel Genomic Island Associated with vanD-Type Vancomycin Resistance in Six Dutch Vancomycin-Resistant Enterococcus faecium Isolates ' , Antimicrobial Agents and Chemotherapy , vol. 62 , no. 3 , e01793-17 . https://doi.org/10.1128/AAC.01793-17

Title: Identification of a Novel Genomic Island Associated with vanD-Type Vancomycin Resistance in Six Dutch Vancomycin-Resistant Enterococcus faecium Isolates
Author: Top, Janetta; Sinnige, Jan C.; Brouwer, Ellen C.; Werner, Guido; Corander, Jukka; Severin, Juliette A.; Jansen, Rogier; Bathoorn, E.; Bonten, Marc J. M.; Rossen, John W. A.; Willems, Rob J. L.
Contributor: University of Helsinki, Jukka Corander / Principal Investigator
Date: 2018-03
Language: eng
Number of pages: 7
Belongs to series: Antimicrobial Agents and Chemotherapy
ISSN: 0066-4804
URI: http://hdl.handle.net/10138/299784
Abstract: Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) isolates with four vanD gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the vanD-containing genomic island was not species specific, suggesting that this island is transferred horizontally between enterococci and anaerobic gut commensals.
Subject: Enterococcus faecium
genomic island
vanD type
vancomycin resistance
MOLECULAR CHARACTERIZATION
CONJUGATIVE ELEMENTS
GENE-CLUSTER
FAECALIS
CANADA
FLORA
1183 Plant biology, microbiology, virology
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