Morphology and histology of silent and symptom-causing atherosclerotic carotid plaques - Rationale and design of the Helsinki Carotid Endarterectomy Study 2 (the HeCES2)

Show full item record



Permalink

http://hdl.handle.net/10138/299790

Citation

Nuotio , K , Ijäs , P , Heikkilä , H M , Koskinen , S M , Saksi , J , Vikatmaa , P , Sorto , P , Mäkitie , L , Eriksson , H , Kasari , S , Silvennoinen , H , Valanne , L , Mäyränpää , M I , Kovanen , P T , Soinne , L & Lindsberg , P J 2018 , ' Morphology and histology of silent and symptom-causing atherosclerotic carotid plaques - Rationale and design of the Helsinki Carotid Endarterectomy Study 2 (the HeCES2) ' , Annals of Medicine , vol. 50 , no. 6 , pp. 501-510 . https://doi.org/10.1080/07853890.2018.1494851

Title: Morphology and histology of silent and symptom-causing atherosclerotic carotid plaques - Rationale and design of the Helsinki Carotid Endarterectomy Study 2 (the HeCES2)
Author: Nuotio, Krista; Ijäs, Petra; Heikkilä, Hanna M.; Koskinen, Suvi M.; Saksi, Jani; Vikatmaa, Pirkka; Sorto, Pia; Mäkitie, Laura; Eriksson, Henrietta; Kasari, Sonja; Silvennoinen, Heli; Valanne, Leena; Mäyränpää, Mikko I.; Kovanen, Petri T.; Soinne, Lauri; Lindsberg, Perttu J.
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, Clinicum
University of Helsinki, Perttu Lindsberg / Principal Investigator
University of Helsinki, Department of Neurosciences
University of Helsinki, Research Programs Unit
University of Helsinki, Verisuonikirurgian yksikkö
University of Helsinki, Research Programme for Molecular Neurology
University of Helsinki, HUS Neurocenter
University of Helsinki, HUS Neurocenter
University of Helsinki, Research Programme for Molecular Neurology
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, HUSLAB
University of Helsinki, Wihuri Research Institute
University of Helsinki, Clinicum
University of Helsinki, HUS Neurocenter
Date: 2018
Language: eng
Number of pages: 10
Belongs to series: Annals of Medicine
ISSN: 0785-3890
URI: http://hdl.handle.net/10138/299790
Abstract: Introduction: Every fifth ischemic stroke is caused by thromboembolism originating from an atherosclerotic carotid artery plaque. While prevention is the most cost-effective stroke therapy, antiplatelet and cholesterol-lowering drugs have a ceiling effect in their efficacy. Therefore, discovery of novel pathophysiologic targets are needed to improve the primary and secondary prevention of stroke. This article provides a detailed study design and protocol of HeCES2, an observational prospective cohort study with the objective to investigate the pathophysiology of carotid atherosclerosis.Materials and Methods: Recruitment and carotid endarterectomies of the study patients with carotid atherosclerosis were performed from October 2012 to September 2015. After brain and carotid artery imaging, endarterectomised carotid plaques (CPs) and blood samples were collected from 500 patients for detailed biochemical and molecular analyses.Findings to date: We developed a morphological grading for macroscopic characteristics within CPs. The dominant macroscopic CP characteristics were: smoothness 62%, ulceration 61%, intraplaque hemorrhage 60%, atheromatous gruel 59%, luminal coral-type calcification 34%, abundant (44%) and moderate (39%) intramural calcification, and symptom-causing hot spot area 53%.Future plans: By combining clinically oriented and basic biomedical research, this large-scale study attempts to untangle the pathophysiological perplexities of human carotid atherosclerosis.Key MessagesThis article is a rationale and design of the HeCES2 study that is an observational prospective cohort study with the objective to investigate the pathophysiology of carotid atherosclerosis.The HeCES2 study strives to develop diagnostic algorithms including radiologic imaging to identify carotid atherosclerosis patients who warrant surgical treatment.In addition, the study aims at finding out new tools for clinical risk stratification as well as novel molecular targets for drug development.
Subject: Atherosclerosis
carotid endarterectomy
carotid stenosis
stroke
VULNERABLE PLAQUE
OCCLUSIVE DISEASE
ISCHEMIC-STROKE
ARTERY-DISEASE
EXPRESSION
CORONARY
RISK
STENOSIS
PATIENT
PROTEIN
3112 Neurosciences
3124 Neurology and psychiatry
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Morphology_and_ ... Carotid_Endarterectomy.pdf 3.380Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record