The Long-Term Footprint of Endometriosis : Population-Based Cohort Analysis Reveals Increased Pain Symptoms and Decreased Pain Tolerance at Age 46 Years

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Vuontisjarvi , S , Rossi , H-R , Herrala , S , Morin-Papunen , L , Tapanainen , J S , Karjula , S , Karppinen , J , Auvinen , J & Piltonen , T T 2018 , ' The Long-Term Footprint of Endometriosis : Population-Based Cohort Analysis Reveals Increased Pain Symptoms and Decreased Pain Tolerance at Age 46 Years ' , Journal of Pain , vol. 19 , no. 7 , pp. 754-763 . https://doi.org/10.1016/j.jpain.2018.02.005

Title: The Long-Term Footprint of Endometriosis : Population-Based Cohort Analysis Reveals Increased Pain Symptoms and Decreased Pain Tolerance at Age 46 Years
Author: Vuontisjarvi, Saara; Rossi, Henna-Riikka; Herrala, Sauli; Morin-Papunen, Laure; Tapanainen, Juha S.; Karjula, Salla; Karppinen, Jaro; Auvinen, Juha; Piltonen, Terhi T.
Contributor: University of Helsinki, Reproductive Disease Modeling
Date: 2018-07
Language: eng
Number of pages: 10
Belongs to series: Journal of Pain
ISSN: 1526-5900
URI: http://hdl.handle.net/10138/299818
Abstract: Previous studies have shown increased pain sensitivity in fertile-aged women with endometriosis in response to mechanical stimuli. As yet, population-based studies on the association of endometriosis with pain sensation and pain symptoms in late fertile age are lacking. The main objective of this population-based cohort study was to investigate whether a history of endometriosis is associated with altered pain sensation and musculoskeletal pain symptoms at age 46 years. Our data are derived from the Northern Finland Birth Cohort 1966, which contains postal questionnaire data (72% response rate) as well as clinical data assessing pressure-pain threshold and maximal pain tolerance. The study population consisted of 284 women with endometriosis and 3,390 controls. Our results showed that at age 46 women with a history of endometriosis had a 5.3% lower pressure-pain threshold and 5.1% lower maximal pain tolerance compared with controls. The most significant contributors besides endometriosis were anxiety, depression, and current smoking status. Women with endometriosis also reported an increased number of pain sites (0 pain sites, 9.6 vs 17.9%; 5-8 pain sites, 24.8 vs 19.1%, endometriosis vs controls respectively; P Perspective: This population-based cohort study showed decreased pain threshold and maximal pain tolerance in women with endometriosis in the late fertile age of 46 years. The pain was also found to be more bothersome and intense compared with controls. (C) 2018 by the American Pain Society
Subject: Endometriosis
pain threshold
pain tolerance
premenopause
CHRONIC PELVIC PAIN
QUALITY-OF-LIFE
PRESSURE PAIN
WOMEN
SENSITIVITY
DISORDERS
SENSITIZATION
PATHOGENESIS
MECHANISMS
IMPACT
3112 Neurosciences
3124 Neurology and psychiatry
3123 Gynaecology and paediatrics
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