Beta2-Integrins and Interacting Proteins in Leukocyte Trafficking, Immune Suppression, and Immunodeficiency Disease

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Fagerholm , S C , Guenther , C , Asens , M L , Savinko , T & Uotila , L M 2019 , ' Beta2-Integrins and Interacting Proteins in Leukocyte Trafficking, Immune Suppression, and Immunodeficiency Disease ' , Frontiers in Immunology , vol. 10 , 254 . https://doi.org/10.3389/fimmu.2019.00254

Title: Beta2-Integrins and Interacting Proteins in Leukocyte Trafficking, Immune Suppression, and Immunodeficiency Disease
Author: Fagerholm, Susanna C.; Guenther, Carla; Asens, Marc Llort; Savinko, Terhi; Uotila, Liisa M.
Contributor: University of Helsinki, Integrins in immunity
University of Helsinki, Integrins in immunity
University of Helsinki, External Funding
University of Helsinki, Research Services
Date: 2019-02-19
Language: eng
Number of pages: 10
Belongs to series: Frontiers in Immunology
ISSN: 1664-3224
URI: http://hdl.handle.net/10138/299951
Abstract: Beta2-integrins are complex leukocyte-specific adhesion molecules that are essential for leukocyte (e.g., neutrophil, lymphocyte) trafficking, as well as for other immunological processes such as neutrophil phagocytosis and ROS production, and T cell activation. Intriguingly, however, they have also been found to negatively regulate cytokine responses, maturation, and migratory responses in myeloid cells such as macrophages and dendritic cells, revealing new, and unexpected roles of these molecules in immunity. Because of their essential role in leukocyte function, a lack of expression or function of beta2-integrins causes rare immunodeficiency syndromes, Leukocyte adhesion deficiency type I, and type III (LAD-I and LAD-III). LAD-I is caused by reduced or lost expression of beta2-integrins, whilst in LAD-III, beta2-integrins are expressed but dysfunctional because a major integrin cytoplasmic regulator, kindlin-3, is mutated. Interestingly, some LAD-related phenotypes such as periodontitis have recently been shown to be due to an uncontrolled inflammatory response rather than to an uncontrolled infection, as was previously thought. This review will focus on the recent advances concerning the regulation and functions of beta2-integrins in leukocyte trafficking, immune suppression, and immune deficiency disease.
Subject: integrin
trafficking
kindlin-3
leukocyte adhesion deficiency
leukocyte adhesion cascade
T-CELL-ACTIVATION
ADHESION DEFICIENCY TYPE-1
BETA(2) INTEGRINS
NEUTROPHIL RECRUITMENT
CYTOPLASMIC TAIL
MAC-1 CD11B/CD18
DENDRITIC CELLS
DISTINCT
LFA-1
RESPONSES
3111 Biomedicine
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