IL-10 polymorphisms+434T/C,+504G/T, and-2849C/T may predispose to tubulointersititial nephritis and uveitis in pediatric population

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Rytkönen , S , Ritari , J , Peräsaari , J , Saarela , V , Nuutinen , M & Jahnukainen , T 2019 , ' IL-10 polymorphisms+434T/C,+504G/T, and-2849C/T may predispose to tubulointersititial nephritis and uveitis in pediatric population ' , PLoS One , vol. 14 , no. 2 , 0211915 . https://doi.org/10.1371/journal.pone.0211915

Title: IL-10 polymorphisms+434T/C,+504G/T, and-2849C/T may predispose to tubulointersititial nephritis and uveitis in pediatric population
Author: Rytkönen, Sari; Ritari, Jarmo; Peräsaari, Juha; Saarela, Ville; Nuutinen, Matti; Jahnukainen, Timo
Contributor: University of Helsinki, Children's Hospital
Date: 2019-02-19
Language: eng
Number of pages: 9
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/299982
Abstract: Background Tubulointerstitial nephritis (TIN) and uveitis syndrome (TINU) are likely to be autoimmune diseases. Based on previous studies, adults with isolated idiopathic uveitis have polymorphisms in interleukin 10 (IL-10) and tumor necrosis factor a (TNF-alpha) genes. We aimed to evaluate the presence of IL-10 and TNF-alpha polymorphisms in a nationwide cohort of pediatric TIN/TINU patients. Methods Single nucleotide polymorphisms in IL-10 (+434T/C, +504G/T, -1082G/A, -2849C/T) and in TNF alpha (-308G/A, -238G/A, -857C/T) genes were genotyped in 30 well-defined pediatric patients with idiopathic TIN/TINU syndrome. Control group frequencies for these SNPs were obtained from 393 independent Finnish subjects. Results The homozygous minor allele in IL-10 +434T (rs2222202) and IL-10+504G (rs3024490) was found in all patients with TIN or TINU syndrome while the frequency of these minor alleles in the control population was 44% and 23%, respectively (p <0.001). In IL-10 SNP -2849 (rs6703630) a significant difference was found with genotype TT in all patients (p = 0.004) and in subgroups with TINU syndrome (p = 0.017) and TINU syndrome with chronic uveitis (p = 0.01) compared to reference population. There were no statistical differences in any of the studied TNF-alpha genotypes between TIN/TINU patients and control population. Conclusions A significant difference in the frequency of IL-10+434T and +504G alleles was found between TIN/TINU patients and control population. Genotype -2849TT was more frequently present in patients with TINU syndrome than in the reference subjects. Genetic variation in the inflammatory mediators may predispose to autoimmune nephritis and uveitis.
Subject: ACUTE INTERSTITIAL NEPHRITIS
TUBULOINTERSTITIAL NEPHRITIS
CYTOKINE PRODUCTION
GENE POLYMORPHISM
HLA-DR
INTERLEUKIN-10
ASSOCIATION
CHILDREN
DISEASE
SUSCEPTIBILITY
3123 Gynaecology and paediatrics
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