Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes

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http://hdl.handle.net/10138/299988

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Lamichhane , S , Ahonen , L , Dyrlund , T S , Dickens , A M , Siljander , H , Hyöty , H , Ilonen , J , Toppari , J , Veijola , R , Hyötyläinen , T , Knip , M & Oresic , M 2019 , ' Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes ' , Biomolecules , vol. 9 , no. 1 , 33 . https://doi.org/10.3390/biom9010033

Titel: Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes
Författare: Lamichhane, Santosh; Ahonen, Linda; Dyrlund, Thomas Sparholt; Dickens, Alex M.; Siljander, Heli; Hyöty, Heikki; Ilonen, Jorma; Toppari, Jorma; Veijola, Riitta; Hyötyläinen, Tuulia; Knip, Mikael; Oresic, Matej
Upphovmannens organisation: Diabetes and Obesity Research Program
HUS Children and Adolescents
Research Programs Unit
Children's Hospital
Clinicum
University of Helsinki
Lastentautien yksikkö
Datum: 2019-01
Språk: eng
Sidantal: 9
Tillhör serie: Biomolecules
ISSN: 2218-273X
DOI: https://doi.org/10.3390/biom9010033
Permanenta länken (URI): http://hdl.handle.net/10138/299988
Abstrakt: Previous studies suggest that children who progress to type 1 diabetes (T1D) later in life already have an altered serum lipid molecular profile at birth. Here, we compared cord blood lipidome across the three study groups: children who progressed to T1D (PT1D; n = 30), children who developed at least one islet autoantibody but did not progress to T1D during the follow-up (P1Ab; n = 33), and their age-matched controls (CTR; n = 38). We found that phospholipids, specifically sphingomyelins, were lower in T1D progressors when compared to P1Ab and the CTR. Cholesterol esters remained higher in PT1D when compared to other groups. A signature comprising five lipids was predictive of the risk of progression to T1D, with an area under the receiver operating characteristic curve (AUROC) of 0.83. Our findings provide further evidence that the lipidomic profiles of newborn infants who progress to T1D later in life are different from lipidomic profiles in P1Ab and CTR.
Subject: type 1 diabetes
cord blood
lipidomics
metabolomics
autoimmunity
METABOLISM
PHOSPHATIDYLCHOLINE
DISCOVERY
3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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