Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes

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dc.contributor.author Lamichhane, Santosh
dc.contributor.author Ahonen, Linda
dc.contributor.author Dyrlund, Thomas Sparholt
dc.contributor.author Dickens, Alex M.
dc.contributor.author Siljander, Heli
dc.contributor.author Hyöty, Heikki
dc.contributor.author Ilonen, Jorma
dc.contributor.author Toppari, Jorma
dc.contributor.author Veijola, Riitta
dc.contributor.author Hyötyläinen, Tuulia
dc.contributor.author Knip, Mikael
dc.contributor.author Oresic, Matej
dc.date.accessioned 2019-03-08T11:48:01Z
dc.date.available 2019-03-08T11:48:01Z
dc.date.issued 2019-01
dc.identifier.citation Lamichhane , S , Ahonen , L , Dyrlund , T S , Dickens , A M , Siljander , H , Hyöty , H , Ilonen , J , Toppari , J , Veijola , R , Hyötyläinen , T , Knip , M & Oresic , M 2019 , ' Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes ' , Biomolecules , vol. 9 , no. 1 , 33 . https://doi.org/10.3390/biom9010033
dc.identifier.other PURE: 122514442
dc.identifier.other PURE UUID: 545c3d63-9c14-41ab-9dd8-3b3c33a6f056
dc.identifier.other WOS: 000458051700033
dc.identifier.other Scopus: 85060365305
dc.identifier.uri http://hdl.handle.net/10138/299988
dc.description.abstract Previous studies suggest that children who progress to type 1 diabetes (T1D) later in life already have an altered serum lipid molecular profile at birth. Here, we compared cord blood lipidome across the three study groups: children who progressed to T1D (PT1D; n = 30), children who developed at least one islet autoantibody but did not progress to T1D during the follow-up (P1Ab; n = 33), and their age-matched controls (CTR; n = 38). We found that phospholipids, specifically sphingomyelins, were lower in T1D progressors when compared to P1Ab and the CTR. Cholesterol esters remained higher in PT1D when compared to other groups. A signature comprising five lipids was predictive of the risk of progression to T1D, with an area under the receiver operating characteristic curve (AUROC) of 0.83. Our findings provide further evidence that the lipidomic profiles of newborn infants who progress to T1D later in life are different from lipidomic profiles in P1Ab and CTR. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Biomolecules
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject type 1 diabetes
dc.subject cord blood
dc.subject lipidomics
dc.subject metabolomics
dc.subject autoimmunity
dc.subject METABOLISM
dc.subject PHOSPHATIDYLCHOLINE
dc.subject DISCOVERY
dc.subject 3111 Biomedicine
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes en
dc.type Article
dc.contributor.organization Diabetes and Obesity Research Program
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Research Programs Unit
dc.contributor.organization Children's Hospital
dc.contributor.organization Clinicum
dc.contributor.organization University of Helsinki
dc.contributor.organization Lastentautien yksikkö
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3390/biom9010033
dc.relation.issn 2218-273X
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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