Ornithine decarboxylase antizyme inhibitor 2 (AZIN2) is a signature of secretory phenotype and independent predictor of adverse prognosis in colorectal cancer

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Kaprio , T , Rasila , T , Hagström , J , Mustonen , H , Lankila , P , Haglund , C & Andersson , L C 2019 , ' Ornithine decarboxylase antizyme inhibitor 2 (AZIN2) is a signature of secretory phenotype and independent predictor of adverse prognosis in colorectal cancer ' , PLoS One , vol. 14 , no. 2 , 0211564 . https://doi.org/10.1371/journal.pone.0211564

Title: Ornithine decarboxylase antizyme inhibitor 2 (AZIN2) is a signature of secretory phenotype and independent predictor of adverse prognosis in colorectal cancer
Author: Kaprio, Tuomas; Rasila, Tiina; Hagström, Jaana; Mustonen, Harri; Lankila, Petri; Haglund, Caj; Andersson, Leif C.
Contributor: University of Helsinki, Department of Surgery
University of Helsinki, STEMM - Stem Cells and Metabolism Research Program
University of Helsinki, Medicum
University of Helsinki, Clinicum
University of Helsinki, Department of Pathology
University of Helsinki, Department of Surgery
University of Helsinki, Department of Pathology
Date: 2019-02-15
Language: eng
Number of pages: 13
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/299990
Abstract: Ornithine decarboxylase (ODC) is the rate-limiting enzyme of polyamine synthesis. The two ODC antizyme inhibitors (AZIN1) and (AZIN2) are regulators of the catalytic activity of ODC. While AZIN1 is a regulator of cell proliferation, AZIN2 is involved in intracellular vesicle transport and secretion. There are no previous reports on the impact of AZIN2 expression in human cancer. We applied immunohistochemistry with antibodies to human AZIN2 on tissue micro- arrays of colorectal cancers (CRC) from 840 patients with a median follow-up of 5.1 years (range 0-25.8). The 5-year disease-specific survival rate was 58.9% (95% CI 55.0-62.8%). High AZIN2 expression was associated with mucinous histology (p = 0.002) and location in the right hemicolon (p = 0.021). We found no association with age, gender, stage, or histological tumor grade. High tumor expression of AZIN2 predicted an unfavorable prognosis (p
Subject: EXPRESSION
CELLS
METASTASIS
RAB27A
GENE
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
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