Total joint replacement in inhibitor-positive haemophilia : Long-term outcome analysis in fifteen patients

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Danielson , H , Lassila , R , Ylinen , P & Yrjönen , T 2017 , ' Total joint replacement in inhibitor-positive haemophilia : Long-term outcome analysis in fifteen patients ' , World journal of orthopedics , vol. 8 , no. 10 , pp. 777-784 . https://doi.org/10.5312/wjo.v8.i10.777

Title: Total joint replacement in inhibitor-positive haemophilia : Long-term outcome analysis in fifteen patients
Author: Danielson, Heidi; Lassila, Riitta; Ylinen, Pekka; Yrjönen, Timo
Contributor: University of Helsinki, University of Helsinki
Date: 2017-10-18
Language: eng
Number of pages: 8
Belongs to series: World journal of orthopedics
ISSN: 2218-5836
URI: http://hdl.handle.net/10138/299991
Abstract: AIM To collect data from joint replacement in inhibitor patients, evaluate haemostatic and patient outcomes, and analyse the costs. METHODS We report our 21-year, single-centre cumulative experience of 15 joint arthroplasties in six inhibitor patients. RESULTS Two low responder inhibitor patients were in the early days treated with FVIII, whereas bypassing agents were used in the rest of the high responder patients. The primary haemostatic outcome was good in 8/15, fair in 4/15 and poor in 3/15 operations. The overall patient outcome, including joint health and patient satisfaction, was good in 10/15, fair 4/15 and poor in 1/15. No deep infections were observed. Cost analysis was most beneficial in low responders and in two immune-tolerized, high responder patients. In all cases, factor replacement comprised the main treatment costs. CONCLUSION Our experience supports the initial use of bypassing agents as well as preoperative immune-tolerance induction when possible. Despite the challenges of haemostasis and severe joint disease, total joint arthroplasty can reach a good outcome, even in inhibitor patients. The risk for deep infection might be smaller than previously reported. Individual planning, intense multidisciplinary teamwork and execution of operations should be centralised in a professional unit.
Subject: Haemophilia
Joint replacement
Inhibitor
Cost analysis
Arthroplasty
ELECTIVE ORTHOPEDIC-SURGERY
SINGLE-CENTER EXPERIENCE
OF-THE-LITERATURE
BYPASSING AGENTS
TRANEXAMIC ACID
A PATIENTS
SYNOVIORTHESIS
EPIDEMIOLOGY
ARTHROPLASTY
ARTHROPATHY
3126 Surgery, anesthesiology, intensive care, radiology
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