Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity

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TEDDY STUDY GRP , Norris , J M , Lee , H-S , Frederiksen , B , Erlund , I , Toppari , J , Sundvall , J , Virtanen , S M & Knip , M 2018 , ' Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity ' , Diabetes , vol. 67 , no. 1 , pp. 146-154 . https://doi.org/10.2337/db17-0802

Title: Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity
Author: TEDDY STUDY GRP; Norris, Jill M.; Lee, Hye-Seung; Frederiksen, Brittni; Erlund, Iris; Toppari, Jorma; Sundvall, Jouko; Virtanen, Suvi M.; Knip, Mikael
Contributor: University of Helsinki, Children's Hospital
Date: 2018-01-01
Language: eng
Number of pages: 9
Belongs to series: Diabetes
ISSN: 0012-1797
URI: http://hdl.handle.net/10138/299995
Abstract: We examined the association between plasma 25-hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We conducted a risk set sampled nested case-control study of 376 IA case subjects and up to 3 control subjects per case subject. 25(OH)D concentration was measured on all samples prior to, and including, the first IA positive visit. Nine polymorphisms in VDR, CYP24A, CYP27B1, GC, and RXRA were analyzed as effect modifiers of 25(OH)D. Adjusting for HLA-DR-DQ and ancestry, higher childhood 25(OH)D was associated with lower IA risk (odds ratio = 0.93 for a 5 nmol/L difference; 95% CI 0.89, 0.97). Moreover, this association was modified by VDR rs7975232 (interaction P = 0.0072), where increased childhood 25(OH)D was associated with a decreasing IA risk based upon number of minor alleles: 0 (1.00; 0.93, 1.07), 1 (0.92; 0.89, 0.96), and 2 (0.86; 0.80, 0.92). Vitamin D and VDR may have a combined role in IA development in children at increased genetic risk for type 1 diabetes.
Subject: VITAMIN-D STATUS
ENVIRONMENTAL DETERMINANTS
D DEFICIENCY
D LEVEL
ONSET
D-3
POLYMORPHISMS
ASSOCIATION
CHILDREN
1,25-DIHYDROXYVITAMIN-D
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
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