T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma

Show full item record



Permalink

http://hdl.handle.net/10138/300014

Citation

Leivonen , S-K , Pollari , M , Brück , O , Pellinen , T , Autio , M , Karjalainen-Lindsberg , M-L , Mannisto , S , Kellokumpu-Lehtinen , P-L , Kallioniemi , O , Mustjoki , S & Leppä , S 2019 , ' T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma ' , Haematologica , vol. 104 , no. 2 , pp. 338-346 . https://doi.org/10.3324/haematol.2018.200105

Title: T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma
Author: Leivonen, Suvi-Katri; Pollari, Marjukka; Brück, Oscar; Pellinen, Teijo; Autio, Matias; Karjalainen-Lindsberg, Marja-Liisa; Mannisto, Susanna; Kellokumpu-Lehtinen, Pirkko-Liisa; Kallioniemi, Olli; Mustjoki, Satu; Leppä, Sirpa
Contributor organization: Research Programs Unit
Genome-Scale Biology (GSB) Research Program
Clinicum
Department of Oncology
University of Helsinki
Faculty of Medicine
Immunobiology Research Program
Department of Clinical Chemistry and Hematology
Medicum
Institute for Molecular Medicine Finland
Department of Pathology
Sirpa Marianne Leppä / Principal Investigator
Hematologian yksikkö
HUS Comprehensive Cancer Center
Precision Systems Medicine
Date: 2019-02
Language: eng
Number of pages: 9
Belongs to series: Haematologica
ISSN: 0390-6078
DOI: https://doi.org/10.3324/haematol.2018.200105
URI: http://hdl.handle.net/10138/300014
Abstract: Primary testicular lymphoma is a rare lymphoid malignancy, most often, histologically, representing diffuse large B-cell lymphoma. The tumor rnicroenvi.ro.nrnent and limited immune surveillance have a major impact on diffuse large B-cell lymphoma pathogenesis and. survival, but the impact on primary testicular lymphoma is unknown. Here, the purpose of the study was to characterize the tumor microenvironme.nt in primary testicular lymphoma, and associate the findings with outcome. We profiled the expression of 730 immune response enes in 60 primary testicular lymphomas utilizing the Nanostring platorm, and used multiplex imrnunohistochemistry to characterize the immune cell phenotypes in the tumor tissue. We identified a gene signature enriched for T-lymphocyte markers differentially expressed. between the patients. Low expression of the signature predicted poor outcome independently of the International Prognostic Index (progression -free survival: HR=2.810, 95%CI: 1.228-6.431, P=0.014; overall survival: HR=3.267, 95`)/0' CI: 1.406-7.590, P=0.006). The T-lymphocyte signature was associated with outcome also in an independent diffuse large B-cell lymphoma cohort (n=96). Multiplex immunohistochemistry revealed that poor survival of primary testicular lymphoma patients correlated with low percentage of CD3'CD4' and CD3+CD8' tumor-infiltrating lymphocytes (P
Subject: CLASS-II EXPRESSION
INACTIVATION
RITUXIMAB
ANTIBODY
BLINATUMOMAB
LYMPHOCYTES
IPILIMUMAB
SURVIVAL
FEATURES
GENES
3121 General medicine, internal medicine and other clinical medicine
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
338.full.pdf 2.312Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record