Shared heritability and functional enrichment across six solid cancers

Show full item record



Permalink

http://hdl.handle.net/10138/300017

Citation

Jiang , X , Finucane , H K , Schumacher , F R , Schmit , S L , Tyrer , J P , Han , Y , Michailidou , K , Lesseur , C , Kuchenbaecker , K B , Dennis , J , Conti , D V , Casey , G , Gaudet , M M , Huyghe , J R , Albanes , D , Aldrich , M C , Andrew , A S , Andrulis , I L , Anton-Culver , H , Antoniou , A C , Antonenkova , N N , Arnold , S M , Aronson , K J , Arun , B K , Bandera , E V , Barkardottir , R B , Barnes , D R , Batra , J , Beckmann , M W , Benitez , J , Benlloch , S , Berchuck , A , Berndt , S I , Bickeboeller , H , Bien , S A , Blomqvist , C , Boccia , S , Bogdanova , N V , Bojesen , S E , Bolla , M K , Brauch , H , Brenner , H , Brenton , J D , Brook , M N , Brunet , J , Brunnstrom , H , Buchanan , D D , Burwinkel , B , Butzow , R , Cadoni , G , Caldes , T , Caligo , M A , Campbell , I , Campbell , P T , Cancel-Tassin , G , Cannon-Albright , L , Campa , D , Caporaso , N , Carvalho , A L , Chan , A T , Chang-Claude , J , Chanock , S J , Chen , C , Christiani , D C , Claes , K B M , Claessens , F , Clements , J , Collee , J M , Correa , M C , Couch , F J , Cox , A , Cunningham , J M , Cybulski , C , Czene , K , Daly , M B , defazio , A , Devilee , P , Diez , O , Gago-Dominguez , M , Donovan , J L , Doerk , T , Duell , E J , Dunning , A M , Dwek , M , Eccles , D M , Edlund , C K , Edwards , D R V , Ellberg , C , Evans , D G , Fasching , P A , Ferris , R L , Liloglou , T , Figueiredo , J C , Fletcher , O , Fortner , R T , Fostira , F , Franceschi , S , Friedman , E , Gallinger , S J , Ganz , P A , Garber , J , Garcia-Saenz , J A , Gayther , S A , Giles , G G , Godwin , A K , Goldberg , M S , Goldgar , D E , Goode , E L , Goodman , M T , Goodman , G , Grankvist , K , Greene , M H , Gronberg , H , Gronwald , J , Guenel , P , Hakansson , N , Hall , P , Hamann , U , Hamdy , F C , Hamilton , R J , Hampe , J , Haugen , A , Heitz , F , Herrero , R , Hillemanns , P , Hoffmeister , M , Hogdall , E , Hong , Y-C , Hopper , J L , Houlston , R , Hulick , P J , Hunter , D J , Huntsman , D G , Idos , G , Imyanitov , E N , Ingles , S A , Isaacs , C , Jakubowska , A , James , P , Jenkins , M A , Johansson , M , Johansson , M , John , E M , Joshi , A D , Kaneva , R , Karlan , B Y , Kelemen , L E , Kuhl , T , Khaw , K-T , Khusnutdinova , E , Kibel , A S , Kiemeney , L A , Kim , J , Kjaer , S K , Knight , J A , Kogevinas , M , Kote-Jarai , Z , Koutros , S , Kristensen , V N , Kupryjanczyk , J , Lacko , M , Lam , S , Lambrechts , D , Landi , M T , Lazarus , P , Le , N D , Lee , E , Lejbkowicz , F , Lenz , H-J , Leslie , G , Lessel , D , Lester , J , Levine , D A , Li , L , Li , C I , Lindblom , A , Lindor , N M , Liu , G , Loupakis , F , Lubinski , J , Maehle , L , Maier , C , Mannermaa , A , Le Marchand , L , Margolin , S , May , T , McGuffog , L , Meindl , A , Middha , P , Miller , A , Milne , R L , MacInnis , R J , Modugno , F , Montagna , M , Moreno , V , Moysich , K B , Mucci , L , Muir , K , Mulligan , A M , Nathanson , K L , Neal , D E , Ness , A R , Neuhausen , S L , Nevanlinna , H , Newcomb , P A , Newcomb , L F , Nielsen , F C , Nikitina-Zake , L , Nordestgaard , B G , Nussbaum , R L , Offit , K , Olah , E , Al Olama , A A , Olopade , O I , Olshan , A F , Olsson , H , Osorio , A , Pandha , H , Park , J Y , Pashayan , N , Parsons , M T , Pejovic , T , Penney , K L , Peters , W H M , Phelan , C M , Phipps , A I , Plaseska-Karanfilska , D , Pring , M , Prokofyeva , D , Radice , P , Stefansson , K , Ramus , S J , Raskin , L , Rennert , G , Rennert , H S , van Rensburg , E J , Riggan , M J , Risch , H A , Risch , A , Roobol , M J , Rosenstein , B S , Rossing , M A , De Ruyck , K , Saloustros , E , Sandler , D P , Sawyer , E J , Schabath , M B , Schleutker , J , Schmidt , M K , Setiawan , V W , Shen , H , Siegel , E M , Sieh , W , Singer , C F , Slattery , M L , Sorensen , K D , Southey , M C , Spurdle , A B , Stanford , J L , Stevens , V L , Stintzing , S , Stone , J , Sundfeldt , K , Sutphen , R , Swerdlow , A J , Tajara , E H , Tangen , C M , Tardon , A , Taylor , J A , Teare , M D , Teixeira , M R , Terry , M B , Terry , K L , Thibodeau , S N , Thomassen , M , Bjorge , L , Tischkowitz , M , Toland , A E , Torres , D , Townsend , P A , Travis , R C , Tung , N , Tworoger , S S , Ulrich , C M , Usmani , N , Vachon , C M , Van Nieuwenhuysen , E , Vega , A , Aguado-Barrera , M E , Wang , Q , Webb , P M , Weinberg , C R , Weinstein , S , Weissler , M C , Weitzel , J N , West , C M L , White , E , Whittemore , A S , Wichmann , H-E , Wiklund , F , Winqvist , R , Wolk , A , Woll , P , Woods , M , Wu , A H , Wu , X , Yannoukakos , D , Zheng , W , Zienolddiny , S , Ziogas , A , Zorn , K K , Lane , J M , Saxena , R , Thomas , D , Hung , R J , Diergaarde , B , Mckay , J , Peters , U , Hsu , L , Garcia-Closas , M , Eeles , R A , Chenevix-Trench , G , Brennan , P J , Haiman , C A , Simard , J , Easton , D F , Gruber , S B , Pharoah , P D P , Price , A L , Pasaniuc , B , Amos , C I , Kraft , P & Lindstrom , S 2019 , ' Shared heritability and functional enrichment across six solid cancers ' , Nature Communications , vol. 10 , 431 . https://doi.org/10.1038/s41467-018-08054-4

Title: Shared heritability and functional enrichment across six solid cancers
Author: Jiang, Xia; Finucane, Hilary K.; Schumacher, Fredrick R.; Schmit, Stephanie L.; Tyrer, Jonathan P.; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B.; Dennis, Joe; Conti, David V.; Casey, Graham; Gaudet, Mia M.; Huyghe, Jeroen R.; Albanes, Demetrius; Aldrich, Melinda C.; Andrew, Angeline S.; Andrulis, Irene L.; Anton-Culver, Hoda; Antoniou, Antonis C.; Antonenkova, Natalia N.; Arnold, Susanne M.; Aronson, Kristan J.; Arun, Banu K.; Bandera, Elisa V.; Barkardottir, Rosa B.; Barnes, Daniel R.; Batra, Jyotsna; Beckmann, Matthias W.; Benitez, Javier; Benlloch, Sara; Berchuck, Andrew; Berndt, Sonja I.; Bickeboeller, Heike; Bien, Stephanie A.; Blomqvist, Carl; Boccia, Stefania; Bogdanova, Natalia V.; Bojesen, Stig E.; Bolla, Manjeet K.; Brauch, Hiltrud; Brenner, Hermann; Brenton, James D.; Brook, Mark N.; Brunet, Joan; Brunnstrom, Hans; Buchanan, Daniel D.; Burwinkel, Barbara; Butzow, Ralf; Cadoni, Gabriella; Caldes, Trinidad; Caligo, Maria A.; Campbell, Ian; Campbell, Peter T.; Cancel-Tassin, Geraldine; Cannon-Albright, Lisa; Campa, Daniele; Caporaso, Neil; Carvalho, Andre L.; Chan, Andrew T.; Chang-Claude, Jenny; Chanock, Stephen J.; Chen, Chu; Christiani, David C.; Claes, Kathleen B. M.; Claessens, Frank; Clements, Judith; Collee, J. Margriet; Correa, Marcia Cruz; Couch, Fergus J.; Cox, Angela; Cunningham, Julie M.; Cybulski, Cezary; Czene, Kamila; Daly, Mary B.; defazio, Anna; Devilee, Peter; Diez, Orland; Gago-Dominguez, Manuela; Donovan, Jenny L.; Doerk, Thilo; Duell, Eric J.; Dunning, Alison M.; Dwek, Miriam; Eccles, Diana M.; Edlund, Christopher K.; Edwards, Digna R. Velez; Ellberg, Carolina; Evans, D. Gareth; Fasching, Peter A.; Ferris, Robert L.; Liloglou, Triantafillos; Figueiredo, Jane C.; Fletcher, Olivia; Fortner, Renee T.; Fostira, Florentia; Franceschi, Silvia; Friedman, Eitan; Gallinger, Steven J.; Ganz, Patricia A.; Garber, Judy; Garcia-Saenz, Jose A.; Gayther, Simon A.; Giles, Graham G.; Godwin, Andrew K.; Goldberg, Mark S.; Goldgar, David E.; Goode, Ellen L.; Goodman, Marc T.; Goodman, Gary; Grankvist, Kjell; Greene, Mark H.; Gronberg, Henrik; Gronwald, Jacek; Guenel, Pascal; Hakansson, Niclas; Hall, Per; Hamann, Ute; Hamdy, Freddie C.; Hamilton, Robert J.; Hampe, Jochen; Haugen, Aage; Heitz, Florian; Herrero, Rolando; Hillemanns, Peter; Hoffmeister, Michael; Hogdall, Estrid; Hong, Yun-Chul; Hopper, John L.; Houlston, Richard; Hulick, Peter J.; Hunter, David J.; Huntsman, David G.; Idos, Gregory; Imyanitov, Evgeny N.; Ingles, Sue Ann; Isaacs, Claudine; Jakubowska, Anna; James, Paul; Jenkins, Mark A.; Johansson, Mattias; Johansson, Mikael; John, Esther M.; Joshi, Amit D.; Kaneva, Radka; Karlan, Beth Y.; Kelemen, Linda E.; Kuhl, Tabea; Khaw, Kay-Tee; Khusnutdinova, Elza; Kibel, Adam S.; Kiemeney, Lambertus A.; Kim, Jeri; Kjaer, Susanne K.; Knight, Julia A.; Kogevinas, Manolis; Kote-Jarai, Zsofia; Koutros, Stella; Kristensen, Vessela N.; Kupryjanczyk, Jolanta; Lacko, Martin; Lam, Stephan; Lambrechts, Diether; Landi, Maria Teresa; Lazarus, Philip; Le, Nhu D.; Lee, Eunjung; Lejbkowicz, Flavio; Lenz, Heinz-Josef; Leslie, Goska; Lessel, Davor; Lester, Jenny; Levine, Douglas A.; Li, Li; Li, Christopher I.; Lindblom, Annika; Lindor, Noralane M.; Liu, Geoffrey; Loupakis, Fotios; Lubinski, Jan; Maehle, Lovise; Maier, Christiane; Mannermaa, Arto; Le Marchand, Loic; Margolin, Sara; May, Taymaa; McGuffog, Lesley; Meindl, Alfons; Middha, Pooja; Miller, Austin; Milne, Roger L.; MacInnis, Robert J.; Modugno, Francesmary; Montagna, Marco; Moreno, Victor; Moysich, Kirsten B.; Mucci, Lorelei; Muir, Kenneth; Mulligan, Anna Marie; Nathanson, Katherine L.; Neal, David E.; Ness, Andrew R.; Neuhausen, Susan L.; Nevanlinna, Heli; Newcomb, Polly A.; Newcomb, Lisa F.; Nielsen, Finn Cilius; Nikitina-Zake, Liene; Nordestgaard, Borge G.; Nussbaum, Robert L.; Offit, Kenneth; Olah, Edith; Al Olama, Ali Amin; Olopade, Olufunmilayo I.; Olshan, Andrew F.; Olsson, Hakan; Osorio, Ana; Pandha, Hardev; Park, Jong Y.; Pashayan, Nora; Parsons, Michael T.; Pejovic, Tanja; Penney, Kathryn L.; Peters, Wilbert H. M.; Phelan, Catherine M.; Phipps, Amanda I.; Plaseska-Karanfilska, Dijana; Pring, Miranda; Prokofyeva, Darya; Radice, Paolo; Stefansson, Kari; Ramus, Susan J.; Raskin, Leon; Rennert, Gad; Rennert, Hedy S.; van Rensburg, Elizabeth J.; Riggan, Marjorie J.; Risch, Harvey A.; Risch, Angela; Roobol, Monique J.; Rosenstein, Barry S.; Rossing, Mary Anne; De Ruyck, Kim; Saloustros, Emmanouil; Sandler, Dale P.; Sawyer, Elinor J.; Schabath, Matthew B.; Schleutker, Johanna; Schmidt, Marjanka K.; Setiawan, V. Wendy; Shen, Hongbing; Siegel, Erin M.; Sieh, Weiva; Singer, Christian F.; Slattery, Martha L.; Sorensen, Karina Dalsgaard; Southey, Melissa C.; Spurdle, Amanda B.; Stanford, Janet L.; Stevens, Victoria L.; Stintzing, Sebastian; Stone, Jennifer; Sundfeldt, Karin; Sutphen, Rebecca; Swerdlow, Anthony J.; Tajara, Eloiza H.; Tangen, Catherine M.; Tardon, Adonina; Taylor, Jack A.; Teare, M. Dawn; Teixeira, Manuel R.; Terry, Mary Beth; Terry, Kathryn L.; Thibodeau, Stephen N.; Thomassen, Mads; Bjorge, Line; Tischkowitz, Marc; Toland, Amanda E.; Torres, Diana; Townsend, Paul A.; Travis, Ruth C.; Tung, Nadine; Tworoger, Shelley S.; Ulrich, Cornelia M.; Usmani, Nawaid; Vachon, Celine M.; Van Nieuwenhuysen, Els; Vega, Ana; Aguado-Barrera, Miguel Elias; Wang, Qin; Webb, Penelope M.; Weinberg, Clarice R.; Weinstein, Stephanie; Weissler, Mark C.; Weitzel, Jeffrey N.; West, Catharine M. L.; White, Emily; Whittemore, Alice S.; Wichmann, H-Erich; Wiklund, Fredrik; Winqvist, Robert; Wolk, Alicja; Woll, Penella; Woods, Michael; Wu, Anna H.; Wu, Xifeng; Yannoukakos, Drakoulis; Zheng, Wei; Zienolddiny, Shanbeh; Ziogas, Argyrios; Zorn, Kristin K.; Lane, Jacqueline M.; Saxena, Richa; Thomas, Duncan; Hung, Rayjean J.; Diergaarde, Brenda; Mckay, James; Peters, Ulrike; Hsu, Li; Garcia-Closas, Montserrat; Eeles, Rosalind A.; Chenevix-Trench, Georgia; Brennan, Paul J.; Haiman, Christopher A.; Simard, Jacques; Easton, Douglas F.; Gruber, Stephen B.; Pharoah, Paul D. P.; Price, Alkes L.; Pasaniuc, Bogdan; Amos, Christopher I.; Kraft, Peter; Lindstrom, Sara
Contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Pathology
University of Helsinki, Department of Obstetrics and Gynecology
Date: 2019-01-25
Language: eng
Number of pages: 23
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/300017
Abstract: Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
Subject: GENOME-WIDE ASSOCIATION
SUSCEPTIBILITY LOCI
BREAST-CANCER
RISK-FACTORS
LUNG-CANCER
PARTITIONING HERITABILITY
MENDELIAN RANDOMIZATION
GENETIC ARCHITECTURE
ANALYSES IDENTIFY
CELL-TYPES
3111 Biomedicine
1184 Genetics, developmental biology, physiology
3122 Cancers
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
s41467_018_08054_4.pdf 3.742Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record