Germline variation at 8q24 and prostate cancer risk in men of European ancestry

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dc.contributor.author The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
dc.contributor.author Matejcic, Marco
dc.contributor.author Saunders, Edward J.
dc.contributor.author Taari, Kimmo Olavi
dc.date.accessioned 2019-03-12T12:04:01Z
dc.date.available 2019-03-12T12:04:01Z
dc.date.issued 2018-11-05
dc.identifier.citation The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium , Matejcic , M , Saunders , E J & Taari , K O 2018 , ' Germline variation at 8q24 and prostate cancer risk in men of European ancestry ' , Nature Communications , vol. 9 , no. 1 , 4616 . https://doi.org/10.1038/s41467-018-06863-1
dc.identifier.other PURE: 123173890
dc.identifier.other PURE UUID: b55b6ba6-7698-4955-81a9-e4a52d169250
dc.identifier.other Bibtex: urn:ce5d6aa0fc0fd6cfb721a0fbbc29fe92
dc.identifier.other Scopus: 85056250910
dc.identifier.other ORCID: /0000-0002-0077-4896/work/55353703
dc.identifier.other WOS: 000449269700006
dc.identifier.uri http://hdl.handle.net/10138/300056
dc.description An Author Correction to this article was published on 17 January 2019.
dc.description.abstract Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10 −15 ), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62–4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification. © 2018, The Author(s). fi
dc.description.abstract Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10 −15 ), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62–4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification. © 2018, The Author(s). en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Nature Communications
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3122 Cancers
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.title Germline variation at 8q24 and prostate cancer risk in men of European ancestry en
dc.type Article
dc.contributor.organization University Management
dc.contributor.organization Clinicum
dc.contributor.organization HUS Abdominal Center
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/s41467-018-06863-1
dc.relation.issn 2041-1723
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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