Self-healing and injectable hydrogel for matching skin flap regeneration

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http://hdl.handle.net/10138/300063

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Mao , X , Cheng , R , Zhang , H , Bae , J , Cheng , L , Zhang , L , Deng , L , Cui , W , Zhang , Y , Almeida Santos , H & Sun , X 2019 , ' Self-healing and injectable hydrogel for matching skin flap regeneration ' , Advanced Science , vol. 6 , no. 3 , 1801555 . https://doi.org/10.1002/advs.201801555

Title: Self-healing and injectable hydrogel for matching skin flap regeneration
Author: Mao, Xiyuan; Cheng, Ruoyu; Zhang, Hongbo; Bae, Jinhong; Cheng, Liying; Zhang, Lu; Deng, Lianfu; Cui, Wenguo; Zhang, Yuguang; Almeida Santos, Helder; Sun, Xiaoming
Contributor: University of Helsinki, Shanghai Jiao Tong University School of Medicine
University of Helsinki, Faculty of Pharmacy
Date: 2019-02-06
Language: eng
Number of pages: 10
Belongs to series: Advanced Science
ISSN: 2198-3844
URI: http://hdl.handle.net/10138/300063
Abstract: The fabrication of highly biocompatible hydrogels with multiple unique healing abilities for the whole healing process, for example, multifunctional hydrogels with injectable, degradation, antibacterial, antihypoxic, and wound healing–promoting properties that match the dynamic healing process of skin flap regeneration, is currently a research challenge. Here, a multifunctional and dynamic coordinative polyethylene glycol (PEG) hydrogel with mangiferin liposomes (MF‐Lip@PEG) is developed for clinical applications through Ag–S coordination of four‐arm‐PEG‐SH and Ag+. Compared to MF‐PEG, MF‐Lip@PEG exhibits self‐healing properties, lower swelling percentages, and a longer endurance period. Moreover, the hydrogel exhibits excellent drug dispersibility and release characteristics for slow and persistent drug delivery. In vitro studies show that the hydrogel is biocompatible and nontoxic to cells, and exerts an outstanding neovascularization‐promoting effect. The MF‐Lip@PEG also exhibits a strong cytoprotective effect against hypoxia‐induced apoptosis through regulation of the Bax/Bcl‐2/caspase‐3 pathway. In a random skin flap animal model, the MF‐Lip@PEG is injectable and convenient to deliver into the skin flap, providing excellent anti‐inflammation, anti‐infection, and proneovascularization effects and significantly reducing the skin flap necrosis rate. In general, the MF‐Lip@PEG possesses outstanding multifunctionality for the dynamic healing process of skin flap regeneration.
Subject: 116 Chemical sciences
221 Nano-technology
ANGIOGENESIS
APOPTOSIS
CONTROLLED-RELEASE
DELIVERY
DESIGN
ENDOTHELIAL-CELLS
GROWTH-FACTOR
MANGIFERIN
flap regeneration
liposomes
mangiferin
multifunctional hydrogels
polyethylene glycol
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