Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

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Liu , Z , Li , Y , Li , W , Lian , W , Kemell , M , Hietala , S , Figueiredo , P , Li , L , Mäkilä , E , Ma , M , Salonen , J , Hirvonen , J T , Liu , D , Zhang , H , Deng , X & Santos , H A 2019 , ' Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing ' , Materials Horizons , vol. 6 , no. 2 , pp. 385-393 . https://doi.org/10.1039/c8mh01145a

Title: Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing
Author: Liu, Zehua; Li, Yunzhan; Li, Wei; Lian, Wenhua; Kemell, Marianna; Hietala, Sami; Figueiredo, Patricia; Li, Li; Mäkilä, Ermei; Ma, Ming; Salonen, Jarno; Hirvonen, Jouni T.; Liu, Dongfei; Zhang, Hongbo; Deng, Xianming; Santos, Helder A.
Contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Department of Chemistry
University of Helsinki, Department of Chemistry
University of Helsinki, Preclinical Drug Formulation and Analysis group
University of Helsinki, Drug Research Program
University of Helsinki, Drug Research Program
University of Helsinki, Drug Research Program
Date: 2019-02-01
Language: eng
Number of pages: 9
Belongs to series: Materials Horizons
ISSN: 2051-6347
URI: http://hdl.handle.net/10138/300087
Abstract: Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.
Subject: OXIDIZED DEXTRAN
NANOPARTICLES
ANGIOGENESIS
VEGF
DEFEROXAMINE
HYDROGEL
GEL
EXPRESSION
DELIVERY
RELEASE
116 Chemical sciences
317 Pharmacy
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