Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

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Liu , Z , Li , Y , Li , W , Lian , W , Kemell , M , Hietala , S , Figueiredo , P , Li , L , Mäkilä , E , Ma , M , Salonen , J , Hirvonen , J T , Liu , D , Zhang , H , Deng , X & Santos , H A 2019 , ' Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing ' , Materials Horizons , vol. 6 , no. 2 , pp. 385-393 . https://doi.org/10.1039/c8mh01145a

Title: Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing
Author: Liu, Zehua; Li, Yunzhan; Li, Wei; Lian, Wenhua; Kemell, Marianna; Hietala, Sami; Figueiredo, Patricia; Li, Li; Mäkilä, Ermei; Ma, Ming; Salonen, Jarno; Hirvonen, Jouni T.; Liu, Dongfei; Zhang, Hongbo; Deng, Xianming; Santos, Helder A.
Contributor organization: Faculty of Pharmacy
Preclinical Drug Formulation and Analysis group
Division of Pharmaceutical Chemistry and Technology
Drug Research Program
Department of Chemistry
Polymers
Jouni Hirvonen / Principal Investigator
Helsinki Institute of Life Science HiLIFE
Nanomedicines and Biomedical Engineering
Date: 2019-02-01
Language: eng
Number of pages: 9
Belongs to series: Materials Horizons
ISSN: 2051-6347
DOI: https://doi.org/10.1039/c8mh01145a
URI: http://hdl.handle.net/10138/300087
Abstract: Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.
Subject: OXIDIZED DEXTRAN
NANOPARTICLES
ANGIOGENESIS
VEGF
DEFEROXAMINE
HYDROGEL
GEL
EXPRESSION
DELIVERY
RELEASE
116 Chemical sciences
317 Pharmacy
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion
Funder: Valtion perusrahoitus/hankkeet
SUOMEN AKATEMIA
Helsingin yliopisto
Grant number:



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