Beneficial Effects of GLP-1 Agonist in a Male With Compulsive Food-Related Behavior Associated With Autism

Show full item record



Permalink

http://hdl.handle.net/10138/300115

Citation

Jarvinen , A , Laine , M K , Tikkanen , R & Castren , M L 2019 , ' Beneficial Effects of GLP-1 Agonist in a Male With Compulsive Food-Related Behavior Associated With Autism ' , Frontiers in psychiatry , vol. 10 , 97 . https://doi.org/10.3389/fpsyt.2019.00097

Title: Beneficial Effects of GLP-1 Agonist in a Male With Compulsive Food-Related Behavior Associated With Autism
Author: Jarvinen, Anna; Laine, Merja K.; Tikkanen, Roope; Castren, Maija L.
Contributor: University of Helsinki, Department of Psychiatry
University of Helsinki, Medicum
Date: 2019-03-01
Language: eng
Number of pages: 5
Belongs to series: Frontiers in psychiatry
ISSN: 1664-0640
URI: http://hdl.handle.net/10138/300115
Abstract: Individuals with autism spectrum disorder (ASD) frequently display intensely repetitive, restricted thoughts, and behaviors. These behaviors have similarities to compulsions and/ or obsessions in obsessive compulsive disorder (OCD) and are primarily treated with behaviourally-based interventions and serotonin uptake inhibitors (SSRIs). Due to the lack of treatment responses in many cases, however, new treatments are being sought. Here we report beneficial effects of treatment with liraglutide, a glucagon-like peptide-1 (GLP-1) analog, on severe obsessive food craving, binge eating, weight gain, and behavioral problems in an adolescent male with infantile autism and moderate intellectual impairment. Liraglutide treatment reduced weight and unwanted behavior seemingly by preventing food-related repetitive thoughts and compulsions. Our report provides clinical evidence that GLP-1 signaling pathway may represent a novel target for treating food-related behavioral problems and aggressive behavior in ASD.
Subject: obsessive-compulsive disorder
autism
glucagon-like peptide-1 agonist
intellectual disability
weight
overeating
GLUCAGON-LIKE PEPTIDE-1
SPECTRUM DISORDER
REPETITIVE BEHAVIORS
RECEPTOR AGONISTS
DOUBLE-BLIND
ADULTS
3124 Neurology and psychiatry
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Beneficial_Effects_of_GLP_1_Agonist.pdf 409.3Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record