Proton pumping by cytochrome c oxidase : A 40 year anniversary

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Wikström , M & Sharma , V 2018 , ' Proton pumping by cytochrome c oxidase : A 40 year anniversary ' , Biochimica et Biophysica Acta. Bioenergetics , vol. 1859 , no. 9 , pp. 692-698 . https://doi.org/10.1016/j.bbabio.2018.03.009

Title: Proton pumping by cytochrome c oxidase : A 40 year anniversary
Author: Wikström, Mårten; Sharma, Vivek
Contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Department of Physics
Date: 2018-09
Language: eng
Number of pages: 7
Belongs to series: Biochimica et Biophysica Acta. Bioenergetics
ISSN: 0005-2728
URI: http://hdl.handle.net/10138/300200
Abstract: Abstract Cytochrome c oxidase is a remarkable energy transducer that seems to work almost purely by Coulombic principles without the need for significant protein conformational changes. In recent years it has become possible to follow key partial reactions of the catalytic cycle in real time, both with respect to electron and proton movements. These experiments have largely set the stage for the proton pump mechanism. The structures of the catalytic binuclear heme‑copper site that is common to the huge family of heme‑copper oxidases, are today well understood throughout the catalytic cycle of oxygen reduction to water based on both spectroscopic studies and quantum chemical calculations. Here, we briefly review this progress, and add some recent details into how the proton pump mechanism is protected from failure by leakage.
Subject: 1182 Biochemistry, cell and molecular biology
COUPLED ELECTRON-TRANSFER
HEME-COPPER OXIDASES
PARACOCCUS-DENITRIFICANS
ESCHERICHIA-COLI
OXYGEN REDUCTION
MECHANISM
TRANSLOCATION
MITOCHONDRIA
CHEMISTRY
OXIDATION
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