Astrocytes in Neuropathologies Affecting the Frontal Cortex

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http://hdl.handle.net/10138/300212

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Peteri , U-K , Niukkanen , M & Castren , M L 2019 , ' Astrocytes in Neuropathologies Affecting the Frontal Cortex ' , Frontiers in Cellular Neuroscience , vol. 13 , 44 . https://doi.org/10.3389/fncel.2019.00044

Title: Astrocytes in Neuropathologies Affecting the Frontal Cortex
Author: Peteri, Ulla-Kaisa; Niukkanen, Mikael; Castren, Maija L.
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
Date: 2019-02-12
Language: eng
Number of pages: 9
Belongs to series: Frontiers in Cellular Neuroscience
ISSN: 1662-5102
URI: http://hdl.handle.net/10138/300212
Abstract: To an increasing extent, astrocytes are connected with various neuropathologies. Astrocytes comprise of a heterogeneous population of cells with region- and species-specific properties. The frontal cortex exhibits high levels of plasticity that is required for high cognitive functions and memory making this region especially susceptible to damage. Aberrations in the frontal cortex are involved with several cognitive disorders, including Alzheimer's disease, Huntington's disease and frontotemporal dementia. Human induced pluripotent stem cells (iPSCs) provide an alternative for disease modeling and offer possibilities for studies to investigate pathological mechanisms in a cell type-specific manner. Patient-specific iPSC-derived astrocytes have been shown to recapitulate several disease phenotypes. Addressing astrocyte heterogeneity may provide an improved understanding of the mechanisms underlying neurodegenerative diseases.
Subject: astrocyte
frontal cortex
Alzheimer's disease
Huntington's disease
frontotemporal dementia
neurodegeneration
induced pluripotent stem cells
FIBRILLARY ACIDIC PROTEIN
PREFRONTAL CORTEX
MUTANT HUNTINGTIN
MOUSE MODEL
FRONTOTEMPORAL DEMENTIA
GLUTAMATE RELEASE
INCREASED EXPRESSION
STRIATAL ASTROCYTES
D-SERINE
DISEASE
3112 Neurosciences
3124 Neurology and psychiatry
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