Circulating levels of microRNA 423-5p are associated with 90 day mortality in cardiogenic shock

Show simple item record

dc.contributor University of Helsinki, HUS Heart and Lung Center en
dc.contributor University of Helsinki, Faculty of Medicine en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, HUS Heart and Lung Center en
dc.contributor University of Helsinki, Department of Medicine en
dc.contributor University of Helsinki, HUSLAB en
dc.contributor University of Helsinki, HUS Emergency Medicine and Services en
dc.contributor.author Jäntti, Toni
dc.contributor.author Segersvärd, Heli
dc.contributor.author Tolppanen, Heli
dc.contributor.author Tarvasmäki, Tuukka
dc.contributor.author Lassus, Johan
dc.contributor.author Devaux, Yvan
dc.contributor.author Vausort, Melanie
dc.contributor.author Pulkki, Kari
dc.contributor.author Sionis, Alessandro
dc.contributor.author Bayes-Genis, Antoni
dc.contributor.author Tikkanen, Ilkka
dc.contributor.author Lakkisto, Päivi
dc.contributor.author Harjola, Veli-Pekka
dc.date.accessioned 2019-03-25T09:28:01Z
dc.date.available 2019-03-25T09:28:01Z
dc.date.issued 2019-02
dc.identifier.citation Jäntti , T , Segersvärd , H , Tolppanen , H , Tarvasmäki , T , Lassus , J , Devaux , Y , Vausort , M , Pulkki , K , Sionis , A , Bayes-Genis , A , Tikkanen , I , Lakkisto , P & Harjola , V-P 2019 , ' Circulating levels of microRNA 423-5p are associated with 90 day mortality in cardiogenic shock ' , ESC Heart Failure , vol. 6 , no. 1 , pp. 98-102 . https://doi.org/10.1002/ehf2.12377 en
dc.identifier.issn 2055-5822
dc.identifier.other PURE: 123500953
dc.identifier.other PURE UUID: 098a38ae-f37e-4e2d-9af5-5246b16dd889
dc.identifier.other WOS: 000459632300012
dc.identifier.other Scopus: 85057039565
dc.identifier.other ORCID: /0000-0001-9935-6573/work/55884108
dc.identifier.uri http://hdl.handle.net/10138/300372
dc.description.abstract Aims The role of microRNAs has not been studied in cardiogenic shock. We examined the potential role of miR-423-5p level to predict mortality and associations of miR-423-5p with prognostic markers in cardiogenic shock. Methods and results We conducted a prospective multinational observational study enrolling consecutive cardiogenic shock patients. Blood samples were available for 179 patients at baseline to determine levels of miR-423-5p and other biomarkers. Patients were treated according to local practice. Main outcome was 90 day all-cause mortality. Median miR-423-5p level was significantly higher in 90 day non-survivors [median 0.008 arbitrary units (AU) (interquartile range 0.003-0.017) vs. 0.004 AU (0.002-0.009), P = 0.003]. miR-423-5p level above median was associated with higher lactate (median 3.7 vs. 2.4 mmol/L, P = 0.001) and alanine aminotransferase levels (median 68 vs. 35 IU/L, P <0.001) as well as lower cardiac index (1.8 vs. 2.4, P = 0.04) and estimated glomerular filtration rate (56 vs. 70 mL/min/1.73 m(2), P = 0.002). In Cox regression analysis, miR-423-5p level above median was associated with 90 day all-cause mortality independently of established risk factors of cardiogenic shock [adjusted hazard ratio 1.9 (95% confidence interval 1.2-3.2), P = 0.01]. Conclusions In cardiogenic shock patients, above median level of miR-423-5p at baseline is associated with markers of hypoperfusion and seems to independently predict 90 day all-cause mortality. en
dc.format.extent 5
dc.language.iso eng
dc.relation.ispartof ESC Heart Failure
dc.rights en
dc.subject Cardiogenic shock en
dc.subject microRNA en
dc.subject miR-423-5p en
dc.subject Acute coronary syndrome en
dc.subject Mortality en
dc.subject Prognosis en
dc.subject HEART-FAILURE en
dc.subject MIR-423-5P en
dc.subject BIOMARKER en
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology en
dc.title Circulating levels of microRNA 423-5p are associated with 90 day mortality in cardiogenic shock en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1002/ehf2.12377
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl

Files in this item

Total number of downloads: Loading...

Files Size Format View
J_ntti_et_al_2019_ESC_Heart_Failure.pdf 175.6Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record