Substantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individuals

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Sarin , H V , Lee , J H , Jauhiainen , M , Joensuu , A , Borodulin , K , Männistö , S , Jin , Z , Terwilliger , J D , Isola , V , Ahtiainen , J P , Häkkinen , K , Kristiansson , K , Hulmi , J J & Perola , M 2019 , ' Substantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individuals ' , Scientific Reports , vol. 9 , 3450 . https://doi.org/10.1038/s41598-019-40107-6

Title: Substantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individuals
Author: Sarin, H. V.; Lee, J. H.; Jauhiainen, M.; Joensuu, A.; Borodulin, K.; Männistö, S.; Jin, Z.; Terwilliger, J. D.; Isola, V.; Ahtiainen, J. P.; Häkkinen, K.; Kristiansson, K.; Hulmi, J. J.; Perola, M.
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, Quantitative Genetics
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Department of Physiology
University of Helsinki, Research Programs Unit
Date: 2019-03-05
Language: eng
Number of pages: 14
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/300401
Abstract: ( )The accumulation of fat, especially in visceral sites, is a significant risk factor for several chronic diseases with altered cardiometabolic homeostasis. We studied how intensive long-term weight loss and subsequent weight regain affect physiological changes, by longitudinally interrogating the lipid metabolism and white blood cell transcriptomic markers in healthy, normal-weight individuals. The current study examined 42 healthy, young (age: 27.5 +/- 4.0 years), normal-weight (body mass index, BMI: 23.4 +/- 1.7 kg/m(2)) female athletes, of which 25 belong to the weight loss and regain group (diet group), and 17 to the control group. Participants were evaluated, and fasting blood samples were drawn at three time points: at baseline (PRE); at the end of the weight loss period (MID: 21.1 +/- 3.1 weeks after PRE); and at the end of the weight regain period (POST: 18.4 +/- 2.9 weeks after MID). Following the weight loss period, the diet group experienced a similar to 73% reduction (similar to 0.69 kg) in visceral fat mass (false discovery rate, FDR <2.0 x 10(-16)), accompanied by anti-atherogenic effects on transcriptomic markers, decreased low-grade inflammation (e.g., as alpha(1)-acid glycoprotein (FDR = 3.08 x 10(-13)) and hs-CRP (FDR = 2.44 x 10(-3))), and an increase in functionally important anti-atherogenic high-density lipoprotein -associated metabolites (FDR <0.05). This occurred even though these values were already at favorable levels in these participants, who follow a fitness-lifestyle compared to age- and BMI-matched females from the general population (n = 58). Following the weight regain period, most of the observed beneficial changes in visceral fat mass, and meta bolomic and transcriptomic profiles dissipated. Overall, the beneficial anti-atherogenic effects of weight loss can be observed even in previously healthy, normal-weight individuals.
Subject: HDL PARTICLE-SIZE
BODY-COMPOSITION
PHYSICAL-ACTIVITY
HIGH-RISK
DISEASE RISK
OBESE WOMEN
SERUM
CHOLESTEROL
REDUCTION
PROTEIN
3121 General medicine, internal medicine and other clinical medicine
3111 Biomedicine
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