The effect of length of birth interval on the risk of breast cancer by subtype in grand multiparous women

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Katuwal , S , Tapanainen , J S , Pukkala , E & Kauppila , A 2019 , ' The effect of length of birth interval on the risk of breast cancer by subtype in grand multiparous women ' , BMC Cancer , vol. 19 , 199 . https://doi.org/10.1186/s12885-019-5404-z

Title: The effect of length of birth interval on the risk of breast cancer by subtype in grand multiparous women
Author: Katuwal, Sushmita; Tapanainen, Juha S.; Pukkala, Eero; Kauppila, Antti
Contributor: University of Helsinki, Reproductive Disease Modeling
Date: 2019-03-04
Language: eng
Number of pages: 7
Belongs to series: BMC Cancer
ISSN: 1471-2407
URI: http://hdl.handle.net/10138/300403
Abstract: BackgroundThe length of interval between successive childbirths (birth interval) might influence the incidence of breast cancer, either by stimulating or by inhibiting the factors that are responsible for the initiation of breast cancer or its early development.MethodsThis is a case-control study nested in a cohort of 47,479 Finnish grand-multiparous (GM) women born after 1934, and registered as having had at least five births before 2013. The 1354 women with breast cancer diagnosis were compared with controls (1:5) matched by parity and date of birth of the mother. Conditional logistic regression was used to estimate odds ratios of the risk of ductal and lobular breast cancer subtypes associated with each of the intervals between the 1st and 5th birth, stratified by age at diagnosis. Age at first and last birth before index date were used as covariates.ResultsIncreased intervals between the 1st and 5th births were associated with an increased risk of lobular breast cancer. In contrast, regarding ductal cancer, premenopausal women with shorter length of interval (
Subject: Breast cancer
Aetiology
Risk factor
Birth spacing
Lobular
Ductal
Age at diagnosis
Menopause
Pregnancy
Age at first birth
Age at last birth
birth interval
FULL-TERM PREGNANCY
TRANSIENT INCREASE
AGE
PARITY
EXPERIENCE
CARCINOMA
LACTATION
3122 Cancers
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