High mobility group box 1 promotes radioresistance in esophageal squamous cell carcinoma cell lines by modulating autophagy

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Ma , H , Zheng , S , Zhang , X , Gong , T , Lv , X , Fu , S , Zhang , S , Yin , X , Hao , J , Shan , C & Huang , S 2019 , ' High mobility group box 1 promotes radioresistance in esophageal squamous cell carcinoma cell lines by modulating autophagy ' , Cell Death and Disease , vol. 10 , 136 . https://doi.org/10.1038/s41419-019-1355-1

Title: High mobility group box 1 promotes radioresistance in esophageal squamous cell carcinoma cell lines by modulating autophagy
Author: Ma, Hongbing; Zheng, Shuyu; Zhang, Xiaozhi; Gong, Tuotuo; Lv, Xin; Fu, Shenbo; Zhang, Shuqun; Yin, Xiaoran; Hao, Jingcan; Shan, Changyou; Huang, Shan
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
Date: 2019-02-12
Language: eng
Number of pages: 11
Belongs to series: Cell Death and Disease
ISSN: 2041-4889
URI: http://hdl.handle.net/10138/300434
Abstract: Resistance to radiotherapy results in relapse and treatment failure in locally advanced esophageal squamous cell carcinoma (ESCC). High mobility group box 1 (HMGB1) is reported to be associated with the radioresistance in bladder and breast cancer. However, the role of HMGB1 in the radiotherapy response in ESCC has not been fully elucidated. Here, we investigated the role of HMGB1 to radioresistance in ESCC clinical samples and cell lines. We found that HMGB1 expression was associated with tumor recurrence after postoperative radiotherapy in locally advanced ESCC patients. HMGB1 knockdown in ESCC cells resulted in increased radiosensitivity both in vitro and in vivo. Autophagy level was found depressed in HMGB1 inhibition cells and activation of autophagy brought back cell's radioresistance. Our results demonstrate that HMGB1 activate autophagy and consequently promote radioresistance. HMGB1 may be used as a predictor of poor response to radiotherapy in ESCC patients. Our finding also highlights the importance of the utility of HMGB1 in ESCC radiosensitization.
Subject: POSTOPERATIVE RADIOTHERAPY
CANCER
RADIOSENSITIVITY
RESISTANCE
EXPRESSION
INCREASES
SURVIVAL
HMGB1
1182 Biochemistry, cell and molecular biology
3111 Biomedicine
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