Vascular endothelial growth factor signaling in development and disease

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http://hdl.handle.net/10138/300456

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Karaman , S , Leppänen , V-M & Alitalo , K 2018 , ' Vascular endothelial growth factor signaling in development and disease ' , Development , vol. 145 , no. 14 , 151019 . https://doi.org/10.1242/dev.151019

Title: Vascular endothelial growth factor signaling in development and disease
Author: Karaman, Sinem; Leppänen, Veli-Matti; Alitalo, Kari
Contributor: University of Helsinki, Translational Cancer Biology (TCB) Research Programme
University of Helsinki, Kari Alitalo / Principal Investigator
University of Helsinki, Translational Cancer Biology (TCB) Research Programme
Date: 2018-07-15
Language: eng
Number of pages: 8
Belongs to series: Development
ISSN: 0950-1991
URI: http://hdl.handle.net/10138/300456
Abstract: Vascular endothelial growth factors (VEGFs) are best known for their involvement in orchestrating the development and maintenance of the blood and lymphatic vascular systems. VEGFs are secreted by a variety of cells and they bind to their cognate tyrosine kinase VEGF receptors (VEGFRs) in endothelial cells to elicit various downstream effects. In recent years, there has been tremendous progress in elucidating different VEGF/VEGFR signaling functions in both the blood and lymphatic vascular systems. Here, and in the accompanying poster, we present key elements of the VEGF/VEGFR pathway and highlight the classical and newly discovered functions of VEGF signaling in blood and lymphatic vessel development and pathology.
Subject: VEGF
Receptor tyrosine kinase
Vessels
RECEPTOR TYROSINE KINASE
HIGH-AFFINITY BINDING
VEGF-C
LYMPHATIC VESSELS
IN-VIVO
PHOSPHORYLATION SITES
INDUCED ANGIOGENESIS
PERMEABILITY FACTOR
TUMOR ANGIOGENESIS
PRIMARY LYMPHEDEMA
3111 Biomedicine
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