tACS-mediated modulation of the auditory steady-state response as seen with MEG

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Hyvärinen , P , Choi , D , Demarchi , G , Aarnisalo , A A & Weisz , N 2018 , ' tACS-mediated modulation of the auditory steady-state response as seen with MEG ' , Hearing Research , vol. 364 , pp. 90-95 . https://doi.org/10.1016/j.heares.2018.03.023

Title: tACS-mediated modulation of the auditory steady-state response as seen with MEG
Author: Hyvärinen, Petteri; Choi, Dawoon; Demarchi, Gianpaolo; Aarnisalo, Antti A.; Weisz, Nathan
Contributor organization: Korva-, nenä- ja kurkkutautien klinikka
Department of Ophthalmology and Otorhinolaryngology
University of Helsinki
HUS Head and Neck Center
Date: 2018-07
Language: eng
Number of pages: 6
Belongs to series: Hearing Research
ISSN: 0378-5955
DOI: https://doi.org/10.1016/j.heares.2018.03.023
URI: http://hdl.handle.net/10138/300474
Abstract: Background: Previous studies have shown that transcranial electrical stimulation can be successfully applied during simultaneous MEG measurements. In particular, using beamforming they have established that changes of stimulus induced as well as evoked activity can be inspected during transcranial alternating current stimulation (tACS). Objective/Hypothesis: We studied tACS-mediated changes of the auditory steady-state response (ASSR), hypothesizing that-due to the putatively inhibitory role of alpha oscillations-these evoked responses would be diminished. Methods: We compared ASSRs in conditions with and without 12-Hz and 6.5-Hz sinusoidal 1.5 mA tACS, applied bilaterally over temporal areas. Source-level activity was estimated using a linearly constrained minimum variance beamformer and compared across tACS conditions using paired t-tests following a condition-internal normalization procedure. Conclusions: By separating the electrical and auditory stimulation to non-overlapping parts of the frequency spectrum, we were able to compare auditory-evoked steady-state activity across tACS conditions. We observed a significant decrease in normalized ASSR power in the 12-Hz tACS condition, illustrating that tACS could induce immediate changes in auditory evoked activity. This study sets a methodology to further interrogate the causal roles of oscillatory dynamics in auditory cortices, as well as suggests perspectives for employing tACS in clinical contexts. (C) 2018 Published by Elsevier B.V.
Subject: 3125 Otorhinolaryngology, ophthalmology
1184 Genetics, developmental biology, physiology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion

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