Endocannabinoid Signaling in Embryonic Neuronal Motility and Cell-Cell Contact - Role of mGluR5 and TRPC3 Channels

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Turunen , P M , Louhivuori , L M , Louhivuori , V , Kukkonen , J P & Akerman , K E 2018 , ' Endocannabinoid Signaling in Embryonic Neuronal Motility and Cell-Cell Contact - Role of mGluR5 and TRPC3 Channels ' , Neuroscience , vol. 375 , pp. 135-148 . https://doi.org/10.1016/j.neuroscience.2018.02.005

Title: Endocannabinoid Signaling in Embryonic Neuronal Motility and Cell-Cell Contact - Role of mGluR5 and TRPC3 Channels
Author: Turunen, Pauli M.; Louhivuori, Lauri M.; Louhivuori, Verna; Kukkonen, Jyrki P.; Akerman, Karl E.
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Jyrki Kukkonen / Principal Investigator
University of Helsinki, Karl Åkerman / Principal Investigator
Date: 2018-04-01
Language: eng
Number of pages: 14
Belongs to series: Neuroscience
ISSN: 0306-4522
URI: http://hdl.handle.net/10138/300634
Abstract: Cell-cell communication plays a central role in the guidance of migrating neuronal precursor cells during the development of the cerebral cortex. Endocannabinoids (eCBs) have previously been shown to be one of the central factors regulating neuronal migration. In this study the effects of eCBs on different parameters, expected to affect embryonic cortical neuronal motility have been analyzed in neurosphere-derived neuroblasts using time-lapse microscopy. Increased endogenous production of the endocannabinoid 2-arachidonyl glycerol (2-AG) causes bursts of neuroblast motility. The neuroblasts move longer distances and show a low frequency of turning, and the number of neuron-neuron contacts are reduced. Similar changes occur interfering with the function of the metabotropic glutamate receptor 5 (mGluR5) or its transducer canonical transient receptor potential channel 3 (TRPC3) or the neuregulin receptor ErbB4. Blocking of 2-AG production reverses these effects. The data suggest that eCB-regulated neuronal motility is controlled by mGluR5/TRPC3 activity possibly via NRG/ErbB4 signaling. (C) 2018 IBRO. Published by Elsevier Ltd. All rights reserved.
Subject: 2-AG
endocannabinoids
mGluR5
neuroblast
radial glia
TRPC3
NEURAL PROGENITOR CELLS
METABOTROPIC GLUTAMATE-RECEPTOR
ROSTRAL MIGRATORY STREAM
CENTRAL-NERVOUS-SYSTEM
SUBVENTRICULAR ZONE
MONOACYLGLYCEROL LIPASE
SYNAPTIC-TRANSMISSION
CANNABINOID RECEPTOR
MULTIPOLAR MIGRATION
NEUROTROPHIC FACTOR
3112 Neurosciences
3124 Neurology and psychiatry
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