Glycocalyx Degradation and Inflammation in Cardiac Surgery

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Pesonen , E , Passov , A , Andersson , S , Suojaranta , R , Niemi , T , Raivio , P , Salmenperä , M & Schramko , A 2019 , ' Glycocalyx Degradation and Inflammation in Cardiac Surgery ' , Journal of Cardiothoracic and Vascular Anesthesia , vol. 33 , no. 2 , pp. 341-345 . https://doi.org/10.1053/j.jvca.2018.04.007

Title: Glycocalyx Degradation and Inflammation in Cardiac Surgery
Author: Pesonen, Eero; Passov, Arie; Andersson, Sture; Suojaranta, Raili; Niemi, Tomi; Raivio, Peter; Salmenperä, Markku; Schramko, Alexey
Contributor: University of Helsinki, Clinicum
University of Helsinki, Anestesiologian yksikkö
University of Helsinki, HUS Children and Adolescents
University of Helsinki, Clinicum
University of Helsinki, Anestesiologian yksikkö
University of Helsinki, Clinicum
University of Helsinki, Anestesiologian yksikkö
University of Helsinki, Anestesiologian yksikkö
Date: 2019-02
Language: eng
Number of pages: 5
Belongs to series: Journal of Cardiothoracic and Vascular Anesthesia
ISSN: 1053-0770
URI: http://hdl.handle.net/10138/300636
Abstract: Objective: Experimental inflammation induces degradation of glycocalyx. The authors hypothesized that inflammation is an important determinant of glycocalyx degradation in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Design: A prospective observational study. Setting: Operation theater and intensive care unit of a university hospital. Participants: Two separate prospective patient cohorts. Interventions: Blood samples were collected at 5 perioperative time points in the trial cohort (30 patients) and only preoperatively in the preoperative cohort (35 patients). Plasma syndecan-1 (biomarker of glycocalyx degradation), interleukin-6 (IL-6), IL-8, and IL-10 were measured. Measurements and Main Results: In the trial cohort, preoperative ranges were as follows: 0.8-198 ng/mL for syndecan-1; 0-902 pg/mL for IL-6; 0-314.9 pg/mL for IL-8, and 0-2,909 pg/mL for IL-10. Seven out of 30 patients were outliers in terms of plasma concentrations of syndecan-1 and all cytokines preoperatively. The increase of syndecan-1 was 2.7-fold, and those of IL-6 and IL-8 were both 2.5-fold. The increase of IL-10 was modest. Plasma syndecan-1 correlated with all cytokines preoperatively (IL-6: R = 0.66, p <0.001; IL-8: R = 0.67, p = 0.001; IL-10: R = 0.73, p <0.001) as well as at 6 hours postoperatively (IL-6: R = 0.49, p = 0.006; IL-8: R = 0.43, p = 0.02; IL-10: R = 0.41, p = 0.03) and on the postoperative morning (IL-6: R = 0.57, p = 0.001; IL-8: R = 0.37, p = 0.06; IL-10: R = 0.51, p = 0.005) but not intraoperatively. The preoperative findings of the trial cohort could be confirmed in the preoperative cohort. Conclusions: In patients undergoing cardiac surgery with CPB, inflammation in terms of proinflammatory cytokines IL-6 and IL-8 and anti-inflammatory cytokine IL-10 is associated with glycocalyx degradation measured as plasma syndecan-1 concentrations. (C) 2018 Elsevier Inc. All rights reserved.
Subject: glycocalyx
inflammation
interleukin 6
interleukin 8
interleukin 10
syndecan-1
cardiopulmonary bypass
CARDIOPULMONARY BYPASS CIRCUITS
ENDOTHELIAL GLYCOCALYX
PLASMA-LEVELS
BIOCOMPATIBILITY
HYDROCORTISONE
BARRIER
3126 Surgery, anesthesiology, intensive care, radiology
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