Glycocalyx Degradation and Inflammation in Cardiac Surgery

Show full item record



Pesonen , E , Passov , A , Andersson , S , Suojaranta , R , Niemi , T , Raivio , P , Salmenperä , M & Schramko , A 2019 , ' Glycocalyx Degradation and Inflammation in Cardiac Surgery ' , Journal of Cardiothoracic and Vascular Anesthesia , vol. 33 , no. 2 , pp. 341-345 .

Title: Glycocalyx Degradation and Inflammation in Cardiac Surgery
Author: Pesonen, Eero; Passov, Arie; Andersson, Sture; Suojaranta, Raili; Niemi, Tomi; Raivio, Peter; Salmenperä, Markku; Schramko, Alexey
Contributor organization: Clinicum
Anestesiologian yksikkö
Department of Diagnostics and Therapeutics
University of Helsinki
HUS Perioperative, Intensive Care and Pain Medicine
HUS Children and Adolescents
Children's Hospital
Lastentautien yksikkö
III kirurgian klinikka
Department of Surgery
HUS Heart and Lung Center
Date: 2019-02
Language: eng
Number of pages: 5
Belongs to series: Journal of Cardiothoracic and Vascular Anesthesia
ISSN: 1053-0770
Abstract: Objective: Experimental inflammation induces degradation of glycocalyx. The authors hypothesized that inflammation is an important determinant of glycocalyx degradation in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Design: A prospective observational study. Setting: Operation theater and intensive care unit of a university hospital. Participants: Two separate prospective patient cohorts. Interventions: Blood samples were collected at 5 perioperative time points in the trial cohort (30 patients) and only preoperatively in the preoperative cohort (35 patients). Plasma syndecan-1 (biomarker of glycocalyx degradation), interleukin-6 (IL-6), IL-8, and IL-10 were measured. Measurements and Main Results: In the trial cohort, preoperative ranges were as follows: 0.8-198 ng/mL for syndecan-1; 0-902 pg/mL for IL-6; 0-314.9 pg/mL for IL-8, and 0-2,909 pg/mL for IL-10. Seven out of 30 patients were outliers in terms of plasma concentrations of syndecan-1 and all cytokines preoperatively. The increase of syndecan-1 was 2.7-fold, and those of IL-6 and IL-8 were both 2.5-fold. The increase of IL-10 was modest. Plasma syndecan-1 correlated with all cytokines preoperatively (IL-6: R = 0.66, p <0.001; IL-8: R = 0.67, p = 0.001; IL-10: R = 0.73, p <0.001) as well as at 6 hours postoperatively (IL-6: R = 0.49, p = 0.006; IL-8: R = 0.43, p = 0.02; IL-10: R = 0.41, p = 0.03) and on the postoperative morning (IL-6: R = 0.57, p = 0.001; IL-8: R = 0.37, p = 0.06; IL-10: R = 0.51, p = 0.005) but not intraoperatively. The preoperative findings of the trial cohort could be confirmed in the preoperative cohort. Conclusions: In patients undergoing cardiac surgery with CPB, inflammation in terms of proinflammatory cytokines IL-6 and IL-8 and anti-inflammatory cytokine IL-10 is associated with glycocalyx degradation measured as plasma syndecan-1 concentrations. (C) 2018 Elsevier Inc. All rights reserved.
Subject: glycocalyx
interleukin 6
interleukin 8
interleukin 10
cardiopulmonary bypass
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S1053077018302349_main.pdf 717.4Kb PDF View/Open
1_s2.0_S1053077018302349_main.pdf 479.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record