Process optimization of ecological probe sonication technique for production of rifampicin loaded niosomes

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Khan , D H , Bashir , S , Figueiredo , P , Santos , H A , Khan , M I & Peltonen , L 2019 , ' Process optimization of ecological probe sonication technique for production of rifampicin loaded niosomes ' , Journal of Drug Delivery Science and Technology , vol. 50 , pp. 27-33 . https://doi.org/10.1016/j.jddst.2019.01.012

Title: Process optimization of ecological probe sonication technique for production of rifampicin loaded niosomes
Author: Khan, Daulat Haleem; Bashir, Sajid; Figueiredo, Patricia; Santos, Helder A.; Khan, Muhammad Imran; Peltonen, Leena
Contributor: University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Division of Pharmaceutical Chemistry and Technology
Date: 2019-04
Language: eng
Number of pages: 7
Belongs to series: Journal of Drug Delivery Science and Technology
ISSN: 1773-2247
URI: http://hdl.handle.net/10138/300689
Abstract: The aim of the present study was to develop an optimized niosome formulation for the encapsulation of a poorly water-soluble drug by the ecological probe sonication method. Pluronic L121 and Span 60 were used as surface active agents and the optimization of the composition was made with the aid of Design of Experiment (DoE) concept. Rifampicin was used as a model drug. Concentration levels of charge inducing agent, dicetylphosphate (DCP), and Pluronic L121 were studied as variables. Prepared niosomes with varying concentrations of DCP and Pluronic L121 resulted in small sized niosomes with sizes ranging from 190 nm to 893 nm. During the four weeks stability testing, the particle sizes were reduced slightly. The formulation containing 2 mg of DCP resulted in most stable niosomes with 75.37% entrapment efficiency. All the niosomal formulations showed higher in vitro drug release rates as compared to bulk drug formulation. As a conclusion, rifampicin loaded niosomes prepared with Pluronic L121 and Span 60 resulted in stable, small sized niosomes with improved drug release profile.
Subject: Design of experiment (DoE)
Ecological green technology
Niosomes
Poor solubility
Probe sonication
Rifampicin
IN-VITRO CHARACTERIZATION
VESICULAR SYSTEMS
DELIVERY
FORMULATION
CHOLESTEROL
SOLUBILITY
COPOLYMERS
VARIABLES
DESIGN
317 Pharmacy
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