Meiotic spindle assembly checkpoint and aneuploidy in males versus females

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http://hdl.handle.net/10138/300711

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Lane , S & Kauppi , L 2019 , ' Meiotic spindle assembly checkpoint and aneuploidy in males versus females ' , Cellular and Molecular Life Sciences , vol. 76 , no. 6 , pp. 1135-1150 . https://doi.org/10.1007/s00018-018-2986-6

Title: Meiotic spindle assembly checkpoint and aneuploidy in males versus females
Author: Lane, Simon; Kauppi, Liisa
Contributor: University of Helsinki, Medicum
Date: 2019-03
Language: eng
Number of pages: 16
Belongs to series: Cellular and Molecular Life Sciences
ISSN: 1420-682X
URI: http://hdl.handle.net/10138/300711
Abstract: The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different daughter cells, and meiosis II resembles mitotic divisions in that sister chromatids separate. While in principle the process is identical in males and females, the time frame and susceptibility to chromosomal defects, including achiasmy and cohesion weakening, and the response to mis-segregating chromosomes are not. In this review, we compare and contrast meiotic spindle assembly checkpoint function and aneuploidy in the two sexes.
Subject: Meiosis
Oocyte
Spermatocytes
Chromosome segregation
Aneuploidy
Recombination
Cohesin
Chiasma
Crossover
AURORA-C KINASE
ERROR-PRONE
CHROMOSOME SEGREGATION
PSEUDOAUTOSOMAL REGION
INFERTILE MEN
MOUSE OOCYTES
MEIOSIS-I
PROTEIN
NONDISJUNCTION
ARREST
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
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