Lane , S & Kauppi , L 2019 , ' Meiotic spindle assembly checkpoint and aneuploidy in males versus females ' , Cellular and Molecular Life Sciences , vol. 76 , no. 6 , pp. 1135-1150 . https://doi.org/10.1007/s00018-018-2986-6
Title: | Meiotic spindle assembly checkpoint and aneuploidy in males versus females |
Author: | Lane, Simon; Kauppi, Liisa |
Contributor organization: | Medicum Department of Biochemistry and Developmental Biology Genome Stability Group Faculty of Medicine University of Helsinki |
Date: | 2019-03 |
Language: | eng |
Number of pages: | 16 |
Belongs to series: | Cellular and Molecular Life Sciences |
ISSN: | 1420-682X |
DOI: | https://doi.org/10.1007/s00018-018-2986-6 |
URI: | http://hdl.handle.net/10138/300711 |
Abstract: | The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different daughter cells, and meiosis II resembles mitotic divisions in that sister chromatids separate. While in principle the process is identical in males and females, the time frame and susceptibility to chromosomal defects, including achiasmy and cohesion weakening, and the response to mis-segregating chromosomes are not. In this review, we compare and contrast meiotic spindle assembly checkpoint function and aneuploidy in the two sexes. |
Subject: |
Meiosis
Oocyte Spermatocytes Chromosome segregation Aneuploidy Recombination Cohesin Chiasma Crossover AURORA-C KINASE ERROR-PRONE CHROMOSOME SEGREGATION PSEUDOAUTOSOMAL REGION INFERTILE MEN MOUSE OOCYTES MEIOSIS-I PROTEIN NONDISJUNCTION ARREST 3111 Biomedicine 1182 Biochemistry, cell and molecular biology |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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