The Effect of Low-Dose Aspirin On Serum Placental Growth Factor Levels In a High-Risk PREDO Cohort

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Murtoniemi , K , Vahlberg , T , Hämäläinen , E , Kajantie , E , Pesonen , A K , Räikkönen , K , Taipale , P , Villa , P M & Laivuori , H 2018 , ' The Effect of Low-Dose Aspirin On Serum Placental Growth Factor Levels In a High-Risk PREDO Cohort ' , Pregnancy Hypertension : an international journal of women's cardiovascular health , vol. 13 , pp. 51-57 . https://doi.org/10.1016/j.preghy.2018.04.003

Title: The Effect of Low-Dose Aspirin On Serum Placental Growth Factor Levels In a High-Risk PREDO Cohort
Author: Murtoniemi, K.; Vahlberg, T.; Hämäläinen, E.; Kajantie, E.; Pesonen, A.K.; Räikkönen, K.; Taipale, P.; Villa, P.M.; Laivuori, H.
Contributor: University of Helsinki, Medicum
University of Helsinki, Lastentautien yksikkö
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2018-07
Language: eng
Number of pages: 7
Belongs to series: Pregnancy Hypertension : an international journal of women's cardiovascular health
ISSN: 2210-7789
URI: http://hdl.handle.net/10138/300725
Abstract: Objectives: Our first aim was to study the longitudinal changes of serum placental growth factor (PlGF) concentration between 12(+0) and 28(+0) weeks of gestation in the prospective PREDO cohort. Our second aim was to study the effect of low-dose acetylsalicylic acid (LDA; 100 mg/day), started before the 14th week of gestation, on PlGF concentration. Study design: Blood samples were collected at 12(+0)-14(+0), 18(+0)-20(+0) and 26(+0)-28(+0) weeks of gestation in 101 women without and 309 with clinical risk factors for pre-eclampsia. Risk-women were divided into two groups: to those who had medium risk for pre-eclampsia and to those who had high risk for pre-eclampsia. Finally there were seven groups according to risk, treatment (no prevention/placebo/LDA) and outcome measure pre-eclampsia. Longitudinal changes in the PlGF concentration between groups were compared. To investigate the effect of LDA on serum PlGF concentration, placebo (N = 62) and LDA (N = 61) groups were compared. A repeated measures ANOVA was used to analyze differences in PlGF levels between the groups. Results: The increase in serum PlGF concentration was higher in LDA than in placebo group (time x group effect, p = 0.046). The increase in serum PlGF concentration during pregnancy was lower in high-risk women who had placebo and developed pre-eclampsia and in medium-risk women who developed pre-eclampsia compared to the other women (time x group effect, p <0.001). There were no differences in PlGF change between low-risk women, medium-risk women who did not develop pre-eclampsia, high-risk women in the placebo group without pre-eclampsia and high-risk women in the LDA group with and without pre-eclampsia (p = 0.15). Conclusions: Our finding suggests an association between LDA started before 14 weeks of gestation and higher increase in serum PlGF concentration.
Subject: Pre-eclampsia
Placental growth factor
Low-dose acetylsalicylic acid
Aspirin
BED SPIRAL ARTERIES
16 WEEKS GESTATION
PREVENTING PREECLAMPSIA
MATERNAL CHARACTERISTICS
TROPHOBLAST INVASION
ANTIPLATELET THERAPY
ANGIOGENIC FACTORS
METAANALYSIS
PREGNANCIES
ACCURACY
515 Psychology
3123 Gynaecology and paediatrics
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