Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells

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Häkkinen , S T , Nygren , H , Maiorova , N , Haavikko , R , Alakurtti , S , Yli-Kauhaluoma , J , Rischer , H & Oksman-Caldentey , K-M 2018 , ' Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells ' , Planta Medica , vol. 84 , no. 9/10 , pp. 743-748 . https://doi.org/10.1055/a-0585-6081

Title: Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells
Author: Häkkinen, Suvi T.; Nygren, Heli; Maiorova, Natalia; Haavikko, Raisa; Alakurtti, Sami; Yli-Kauhaluoma, Jari; Rischer, Heiko; Oksman-Caldentey, Kirsi-Marja
Contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Pharmaceutical Design and Discovery group
Date: 2018-07-01
Language: eng
Number of pages: 7
Belongs to series: Planta Medica
ISSN: 0032-0943
URI: http://hdl.handle.net/10138/300734
Abstract: In this study, three semisynthetic betulonic acid-based compounds, 20(29)-dihydrolup-2-en[2,3- d ]isoxazol-28-oic acid, 1-betulonoylpyrrolidine, and lupa-2,20(29)-dieno[2,3- b ]pyrazin-28-oic acid, were studied in biotransformation experiments using Nicotiana tabacum and Catharanthus roseus cell suspension cultures. Biotransformation was performed using cyclodextrin to aid dissolving poorly water-soluble substrates. Several new derivatives were found, consisting of oxidized and glycosylated (pentose- and hexose-conjugated) products.
Subject: ACID
Apocynaceae
CULTURES
Catharanthus roseus
Nicotiana tabacum
Solanaceae
betulinic acid
biotransformation
317 Pharmacy
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