Lifespans of Twins : Does Zygosity Matter?

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Hjelmborg , J , Larsen , P , Kaprio , J , McGue , M , Scheike , T , Hougaard , P & Christensen , K 2019 , ' Lifespans of Twins : Does Zygosity Matter? ' , Genes , vol. 10 , no. 2 , 166 .

Title: Lifespans of Twins : Does Zygosity Matter?
Author: Hjelmborg, Jacob; Larsen, Pia; Kaprio, Jaakko; McGue, Matt; Scheike, Thomas; Hougaard, Philip; Christensen, Kaare
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
Date: 2019-02
Language: eng
Number of pages: 10
Belongs to series: Genes
ISSN: 2073-4425
Abstract: Studies with twins provide fundamental insights to lifespans of humans. We aim to clarify if monozygotic and dizygotic twin individuals differ in lifespan, that is, if zygosity matters. We investigate whether a possible difference in mortality after infancy between zygosities is stable in different age cohorts, and whether the difference remains when twins with unknown zygosity are taken into account. Further, we compare the distribution of long-livers, that is, the upper-tail of the lifespan distribution, between monozygotic and same-sex dizygotic twin individuals. The Danish Twin Registry provides a nationwide cohort of 109,303 twins born during 1870 to 1990 with valid vital status. Standard survival analysis is used to compare mortality in monozygotic and dizygotic twin individuals and twin individuals with unknown zygosity. The mortality of monozygotic and dizygotic twin individuals differs slightly after taking into consideration effects of birth- and age-cohorts, gender differences, and that twins are paired. However, no substantial nor systematic differences remain when taking twins with unknown zygosity into account. Further, the distribution of long-livers is very similar by zygosity, suggesting the same mortality process. The population-based and oldest twin cohort ever studied suggests that monozygotic and dizygotic twins have similar lifespans.
Subject: lifespan
unknown zygosity
cumulative incidence curves
3142 Public health care science, environmental and occupational health
3111 Biomedicine
1184 Genetics, developmental biology, physiology

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