Genome-wide association study of germline variants and breast cancer-specific mortality

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http://hdl.handle.net/10138/300790

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NBCS Collaborators , Escala-Garcia , M , Guo , Q , Doerk , T , Blomqvist , C , Khan , S , Kiiski , J I & Nevanlinna , H 2019 , ' Genome-wide association study of germline variants and breast cancer-specific mortality ' , British Journal of Cancer , vol. 120 , no. 6 , pp. 647-657 . https://doi.org/10.1038/s41416-019-0393-x

Title: Genome-wide association study of germline variants and breast cancer-specific mortality
Author: NBCS Collaborators; Escala-Garcia, Maria; Guo, Qi; Doerk, Thilo; Blomqvist, Carl; Khan, Sofia; Kiiski, Johanna I.; Nevanlinna, Heli
Contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Clinicum
University of Helsinki, Department of Obstetrics and Gynecology
Date: 2019-03-19
Language: eng
Number of pages: 11
Belongs to series: British Journal of Cancer
ISSN: 0007-0920
URI: http://hdl.handle.net/10138/300790
Abstract: BACKGROUND: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS: Meta-analyses included summary estimates based on Cox models of twelve datasets using similar to 10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). RESULTS: We did not find any variant associated with breast cancer-specific mortality at P CONCLUSIONS: We uncovered germline variants on chromosome 7 at BFDP
Subject: SINGLE-NUCLEOTIDE POLYMORPHISMS
GENETIC-VARIATION
SUSCEPTIBILITY LOCI
CLINICAL-OUTCOMES
TUMOR SUBTYPES
SURVIVAL
PROGNOSIS
RISK
PATHWAY
EXPRESSION
3122 Cancers
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