NBCS Collaborators , Escala-Garcia , M , Guo , Q , Doerk , T , Blomqvist , C , Khan , S , Kiiski , J I & Nevanlinna , H 2019 , ' Genome-wide association study of germline variants and breast cancer-specific mortality ' , British Journal of Cancer , vol. 120 , no. 6 , pp. 647-657 . https://doi.org/10.1038/s41416-019-0393-x
Title: | Genome-wide association study of germline variants and breast cancer-specific mortality |
Author: | NBCS Collaborators; Escala-Garcia, Maria; Guo, Qi; Doerk, Thilo; Blomqvist, Carl; Khan, Sofia; Kiiski, Johanna I.; Nevanlinna, Heli |
Contributor organization: | Clinicum Department of Oncology University of Helsinki Department of Obstetrics and Gynecology HUS Gynecology and Obstetrics HUS Comprehensive Cancer Center |
Date: | 2019-03-19 |
Language: | eng |
Number of pages: | 11 |
Belongs to series: | British Journal of Cancer |
ISSN: | 0007-0920 |
DOI: | https://doi.org/10.1038/s41416-019-0393-x |
URI: | http://hdl.handle.net/10138/300790 |
Abstract: | BACKGROUND: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS: Meta-analyses included summary estimates based on Cox models of twelve datasets using similar to 10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). RESULTS: We did not find any variant associated with breast cancer-specific mortality at P CONCLUSIONS: We uncovered germline variants on chromosome 7 at BFDP |
Subject: |
SINGLE-NUCLEOTIDE POLYMORPHISMS
GENETIC-VARIATION SUSCEPTIBILITY LOCI CLINICAL-OUTCOMES TUMOR SUBTYPES SURVIVAL PROGNOSIS RISK PATHWAY EXPRESSION 3122 Cancers |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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