Lehmonen , L , Kaasalainen , T , Atula , S , Mustonen , T & Holmström , M 2019 , ' Myocardial tissue characterization in patients with hereditary gelsolin (AGel) amyloidosis using novel cardiovascular magnetic resonance techniques ' , The international journal of cardiovascular imaging , vol. 35 , no. 2 , pp. 351-358 . https://doi.org/10.1007/s10554-019-01570-4
Title: | Myocardial tissue characterization in patients with hereditary gelsolin (AGel) amyloidosis using novel cardiovascular magnetic resonance techniques |
Author: | Lehmonen, Lauri; Kaasalainen, Touko; Atula, Sari; Mustonen, Tuuli; Holmström, Miia |
Contributor organization: | Department of Physics Department of Diagnostics and Therapeutics Clinicum University of Helsinki HUS Medical Imaging Center Neurologian yksikkö HUS Neurocenter Faculty of Medicine |
Date: | 2019-02 |
Language: | eng |
Number of pages: | 8 |
Belongs to series: | The international journal of cardiovascular imaging |
ISSN: | 1573-0743 |
DOI: | https://doi.org/10.1007/s10554-019-01570-4 |
URI: | http://hdl.handle.net/10138/300872 |
Abstract: | Gelsolin (AGel) amyloidosis is a hereditary condition with common neurological effects. Myocardial involvement, especially strain, T1, or extracellular volume (ECV), in this disease has not been investigated before. Local myocardial effects and possible amyloid accumulation were the targets of interest in this study. Fifty patients with AGel amyloidosis were enrolled in the study. All patients underwent cardiovascular magnetic resonance imaging, including cine imaging, T1 mapping, tagging, and late gadolinium enhancement (LGE) imaging at 1.5 T. Results for volumetry, myocardial feature-tracking strain, rotation, torsion, native T1, ECV, and LGE were investigated. The population mean native T1 values in different segments of the left ventricle (LV) varied between 1003 and 1080 ms. Myocardial mean T1 was 1031 ± 37 ms. T1 was highest in the basal plane of the LV (1055 ± 40 ms), similarly to ECV (30.0% ± 4.4%). ECV correlated with native T1 in all LV segments (p |
Subject: |
AL
Amyloidosis Cardiovascular magnetic resonance Extracellular volume FEATURE-TRACKING Feature tracking HEART T1 T1 mapping Tagging 3126 Surgery, anesthesiology, intensive care, radiology |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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