Myocardial tissue characterization in patients with hereditary gelsolin (AGel) amyloidosis using novel cardiovascular magnetic resonance techniques

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http://hdl.handle.net/10138/300872

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Lehmonen , L , Kaasalainen , T , Atula , S , Mustonen , T & Holmström , M 2019 , ' Myocardial tissue characterization in patients with hereditary gelsolin (AGel) amyloidosis using novel cardiovascular magnetic resonance techniques ' , The international journal of cardiovascular imaging , vol. 35 , no. 2 , pp. 351-358 . https://doi.org/10.1007/s10554-019-01570-4

Title: Myocardial tissue characterization in patients with hereditary gelsolin (AGel) amyloidosis using novel cardiovascular magnetic resonance techniques
Author: Lehmonen, Lauri; Kaasalainen, Touko; Atula, Sari; Mustonen, Tuuli; Holmström, Miia
Contributor: University of Helsinki, Department of Physics
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Neurologian yksikkö
University of Helsinki, Faculty of Medicine
University of Helsinki, Department of Diagnostics and Therapeutics
Date: 2019-02
Language: eng
Number of pages: 8
Belongs to series: The international journal of cardiovascular imaging
ISSN: 1573-0743
URI: http://hdl.handle.net/10138/300872
Abstract: Gelsolin (AGel) amyloidosis is a hereditary condition with common neurological effects. Myocardial involvement, especially strain, T1, or extracellular volume (ECV), in this disease has not been investigated before. Local myocardial effects and possible amyloid accumulation were the targets of interest in this study. Fifty patients with AGel amyloidosis were enrolled in the study. All patients underwent cardiovascular magnetic resonance imaging, including cine imaging, T1 mapping, tagging, and late gadolinium enhancement (LGE) imaging at 1.5 T. Results for volumetry, myocardial feature-tracking strain, rotation, torsion, native T1, ECV, and LGE were investigated. The population mean native T1 values in different segments of the left ventricle (LV) varied between 1003 and 1080 ms. Myocardial mean T1 was 1031 ± 37 ms. T1 was highest in the basal plane of the LV (1055 ± 40 ms), similarly to ECV (30.0% ± 4.4%). ECV correlated with native T1 in all LV segments (p 
Subject: AL
Amyloidosis
Cardiovascular magnetic resonance
Extracellular volume
FEATURE-TRACKING
Feature tracking
HEART
T1
T1 mapping
Tagging
3126 Surgery, anesthesiology, intensive care, radiology
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