Management of clinically N0 neck in oropharyngeal carcinoma

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http://hdl.handle.net/10138/300946

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Jouhi , L , Atula , T , Mäkitie , A & Keski-Santti , H 2019 , ' Management of clinically N0 neck in oropharyngeal carcinoma ' , European Archives of Oto-Rhino-Laryngology , vol. 276 , no. 4 , pp. 1205-1210 . https://doi.org/10.1007/s00405-019-05314-x

Title: Management of clinically N0 neck in oropharyngeal carcinoma
Author: Jouhi, Lauri; Atula, Timo; Mäkitie, Antti; Keski-Santti, Harri
Contributor: University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
University of Helsinki, Korva-, nenä- ja kurkkutautien klinikka
University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
Date: 2019-04
Language: eng
Number of pages: 6
Belongs to series: European Archives of Oto-Rhino-Laryngology
ISSN: 0937-4477
URI: http://hdl.handle.net/10138/300946
Abstract: PurposeOnly a minority of patients with oropharyngeal squamous cell carcinoma (OPSCC) are diagnosed without regional metastasis (cN0). Studies focusing on the management of cN0 neck in OPSCC are scarce.MethodsWe reviewed all OPSCC patients treated at our institution with cN0 neck between 2000 and 2009. The treatment of neck and pattern of regional control was analyzed. Median follow-up was 5years (range 3.5-9.0) or until death.ResultsOf the total 313 OPSCC patients treated within the period, 56 (18%) presented with cN0 neck. Of them, 51 (91%) received completed treatment with curative intent: 46 (90%) underwent elective neck treatment with either neck dissection (chemo)radiotherapy (C)RT (n=23) or (C)RT (n=23). A regional recurrence occurred in three patients (6%) and they all had a p16-negative soft palate midline primary tumor. Two of these patients had received RT on the neck.Conclusions While the overall prognosis of OPSCC is generally favorable and regional recurrences are infrequent, soft palate tumors, that are usually p16 negative, may form an subgroup warranting more aggressive treatment despite the clinical appearance of early stage.
Subject: Head and neck cancer
Oropharynx
Carcinoma
HPV
p16
Regional recurrence
SQUAMOUS-CELL CARCINOMA
LYMPH-NODE BIOPSY
HUMAN-PAPILLOMAVIRUS
ORAL-CAVITY
CANCER
SURVIVAL
HEAD
PREVALENCE
SURGERY
3125 Otorhinolaryngology, ophthalmology
3122 Cancers
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