Jouhi , L , Atula , T , Mäkitie , A & Keski-Santti , H 2019 , ' Management of clinically N0 neck in oropharyngeal carcinoma ' , European Archives of Oto-Rhino-Laryngology , vol. 276 , no. 4 , pp. 1205-1210 . https://doi.org/10.1007/s00405-019-05314-x
Title: | Management of clinically N0 neck in oropharyngeal carcinoma |
Author: | Jouhi, Lauri; Atula, Timo; Mäkitie, Antti; Keski-Santti, Harri |
Contributor organization: | Department of Ophthalmology and Otorhinolaryngology Clinicum Korva-, nenä- ja kurkkutautien klinikka Research Program in Systems Oncology Research Programs Unit University of Helsinki HUS Head and Neck Center |
Date: | 2019-04 |
Language: | eng |
Number of pages: | 6 |
Belongs to series: | European Archives of Oto-Rhino-Laryngology |
ISSN: | 0937-4477 |
DOI: | https://doi.org/10.1007/s00405-019-05314-x |
URI: | http://hdl.handle.net/10138/300946 |
Abstract: | PurposeOnly a minority of patients with oropharyngeal squamous cell carcinoma (OPSCC) are diagnosed without regional metastasis (cN0). Studies focusing on the management of cN0 neck in OPSCC are scarce.MethodsWe reviewed all OPSCC patients treated at our institution with cN0 neck between 2000 and 2009. The treatment of neck and pattern of regional control was analyzed. Median follow-up was 5years (range 3.5-9.0) or until death.ResultsOf the total 313 OPSCC patients treated within the period, 56 (18%) presented with cN0 neck. Of them, 51 (91%) received completed treatment with curative intent: 46 (90%) underwent elective neck treatment with either neck dissection (chemo)radiotherapy (C)RT (n=23) or (C)RT (n=23). A regional recurrence occurred in three patients (6%) and they all had a p16-negative soft palate midline primary tumor. Two of these patients had received RT on the neck.Conclusions While the overall prognosis of OPSCC is generally favorable and regional recurrences are infrequent, soft palate tumors, that are usually p16 negative, may form an subgroup warranting more aggressive treatment despite the clinical appearance of early stage. |
Subject: |
Head and neck cancer
Oropharynx Carcinoma HPV p16 Regional recurrence SQUAMOUS-CELL CARCINOMA LYMPH-NODE BIOPSY HUMAN-PAPILLOMAVIRUS ORAL-CAVITY CANCER SURVIVAL HEAD PREVALENCE SURGERY 3125 Otorhinolaryngology, ophthalmology 3122 Cancers |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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