Tumour budding in oral squamous cell carcinoma : a meta-analysis

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http://hdl.handle.net/10138/300961

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Almangush , A , Pirinen , M , Heikkinen , I , Mäkitie , A A , Salo , T & Leivo , I 2018 , ' Tumour budding in oral squamous cell carcinoma : a meta-analysis ' , British Journal of Cancer , vol. 118 , no. 4 , pp. 577-586 . https://doi.org/10.1038/bjc.2017.425

Title: Tumour budding in oral squamous cell carcinoma : a meta-analysis
Author: Almangush, Alhadi; Pirinen, Matti; Heikkinen, Ilkka; Mäkitie, Antti A.; Salo, Tuula; Leivo, Ilmo
Contributor organization: Oral and Maxillofacial Surgery
Department of Pathology
Medicum
Department of Oral and Maxillofacial Diseases
Department of Mathematics and Statistics
Institute for Molecular Medicine Finland
Helsinki Institute for Information Technology
Department of Public Health
Clinicum
Korva-, nenä- ja kurkkutautien klinikka
Department of Ophthalmology and Otorhinolaryngology
HUS Head and Neck Center
Statistical and population genetics
Date: 2018-02-20
Language: eng
Number of pages: 10
Belongs to series: British Journal of Cancer
ISSN: 0007-0920
DOI: https://doi.org/10.1038/bjc.2017.425
URI: http://hdl.handle.net/10138/300961
Abstract: Background: Tumour budding has been reported as a promising prognostic marker in many cancers. This meta-analysis assessed the prognostic value of tumour budding in oral squamous cell carcinoma (OSCC). Methods: We searched OvidMedline, PubMed, Scopus and Web of Science for articles that studied tumour budding in OSCC. We used reporting recommendations for tumour marker (REMARK) criteria to evaluate the quality of studies eligible for meta-analysis. Results: A total of 16 studies evaluated the prognostic value of tumour budding in OSCC. The meta-analysis showed that tumour budding was significantly associated with lymph node metastasis (odds ratio = 7.08, 95% CI = 1.75-28.73), disease-free survival (hazard ratio = 1.83, 95% CI = 1.34-2.50) and overall survival (hazard ratio = 1.88, 95% CI = 1.25-2.82). Conclusions: Tumour budding is a simple and reliable prognostic marker for OSCC. Evaluation of tumour budding could facilitate personalised management of OSCC.
Subject: tumour budding
oral squamous cell carcinoma
prognosis
marker
invasive front
treatment
survival
EPITHELIAL-MESENCHYMAL TRANSITION
LYMPH-NODE METASTASIS
INDEPENDENT PROGNOSTIC-FACTOR
COLORECTAL-CANCER
POOR-PROGNOSIS
TONGUE CANCER
IMAGE-ANALYSIS
BREAST-CANCER
WORST PATTERN
INVASION
3122 Cancers
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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