How proteolytic inhibitors interact with dentin on glass-fiber post luting over 6 months

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Chaves , L P , Ciantelli , T L , Araujo , D F G , Giacomini , M C , Tjäderhane , L , Candia Scaffa , P M , Honorio , H M & Wang , L 2018 , ' How proteolytic inhibitors interact with dentin on glass-fiber post luting over 6 months ' , Journal of the Mechanical Behavior of Biomedical Materials , vol. 79 , pp. 348-353 . https://doi.org/10.1016/j.jmbbm.2018.01.011

Title: How proteolytic inhibitors interact with dentin on glass-fiber post luting over 6 months
Author: Chaves, Larissa Pinceli; Ciantelli, Thales Lippi; Araujo, Diana F. G.; Giacomini, Marina Ciccone; Tjäderhane, Leo; Candia Scaffa, Polliana Mendes; Honorio, Heitor Marques; Wang, Linda
Contributor: University of Helsinki, Clinicum
Date: 2018-03
Language: eng
Number of pages: 6
Belongs to series: Journal of the Mechanical Behavior of Biomedical Materials
ISSN: 1751-6161
URI: http://hdl.handle.net/10138/300962
Abstract: Objectives: Enzyme inhibitors minimize the degradation of unprotected collagen of dentin promoted by matrix metalloproteinases (MMPs) and cysteine cathepsins (CCs). As the evidence of their effect on the root canal is limited, this study aimed to evaluate the role of EDTA, chlorhexidine and E-64 as antiproteolytic agents on the bond strength (BS) of glass-fiber posts in root canals. Materials and methods: Ninety-six bovine roots were distributed in groups for each time point (n = 8). Adper Scotchbond Multipurpose (MP)/ RelyX ARC system was used to lute the post according to the treatment: negative control (NC)- water, EDTA- 17% ethylenediaminetetraacetic acid, CHX- 2% digluconate chlorhexidine, E-64-5- 5 mu M E-64, E-64-10- 10 mu M E-64 and positive control (PC)- MP associated with activator/ catalyst. Then, slices were subjected to push-out test (0.5 nun/min) after 24 h/6 mons. Data were analyzed by three-way ANOVA/Tukey tests. Failure modes were analyzed (40 x). Results: The factors treatment, time, root canal third and the interaction between treatment and time were statistically significant. At 24 h, no negative interactions were observed among the root dentin, bonding system and post At 6 mons, CHX improved the BS for middle and apical root thirds. Conclusions: CHX was able to promote beneficial BS after 6 mons, which was not noted for any other tested enzyme inhibitors.
Subject: Bond strength
Chlorhexidine
E-64
EDTA
Root canal
CYSTEINE CATHEPSINS
MATRIX METALLOPROTEINASES
RETAINED RESTORATIONS
IN-VITRO
CHLORHEXIDINE
ROOT
DEGRADATION
COLLAGEN
MMPS
METAANALYSIS
313 Dentistry
3111 Biomedicine
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